Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice
| العنوان: | Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice |
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| المؤلفون: | Maria Margarita Canales-Martinez, Judith Salas-Oropeza, Armando Pérez-Torres, Manuel Jiménez-Estrada, Rodolfo Becerril-Millan, M. A. Rodriguez-Monroy, Andrés E. Castell-Rodríguez |
| المصدر: | Molecules Molecules, Vol 25, Iss 1795, p 1795 (2020) Volume 25 Issue 8 |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Phytochemicals, Pharmaceutical Science, Scars, Pharmacology, Article, essential oil, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, Fibroblast migration, law.invention, lcsh:QD241-441, 03 medical and health sciences, Mice, 0302 clinical medicine, lcsh:Organic chemistry, law, Drug Discovery, medicine, Oils, Volatile, Cytotoxic T cell, Animals, Plant Oils, Viability assay, Physical and Theoretical Chemistry, Fibroblast, Essential oil, 030304 developmental biology, Skin, 0303 health sciences, Mice, Inbred BALB C, Wound Healing, integumentary system, Chemistry, Plant Extracts, Organic Chemistry, Bursera, In vitro, medicine.anatomical_structure, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Macrophages, Peritoneal, Molecular Medicine, medicine.symptom, Wound healing, Burseraceae, terpenes |
| الوصف: | Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. It is an endemic tree known as &ldquo aceitillo&rdquo and the antibacterial and antifungal activity of its essential oil has been verified it also acts as an anti-inflammatory. All of these reported biological activities make the essential oil of B. morelensis a candidate to accelerate the wound-healing process. The objective was to determine the wound-healing properties of B. morelensis&rsquo essential oil on a murine model. The essential oil was obtained by hydro-distillation, and the chemical analysis was performed by gas chromatography-mass spectrometry (GC-MS). In the murine model, wound-healing efficacy (WHE) and wound contraction (WC) were evaluated. Cytotoxic activity was evaluated in vitro using peritoneal macrophages from BALB/c mice. The results showed that 18 terpenoid-type compounds were identified in the essential oil. The essential oil had remarkable WHE regardless of the dose and accelerated WC and was not cytotoxic. In vitro tests with fibroblasts showed that cell viability was dose-dependent by adding 1 mg/mL of essential oil (EO) to the culture medium, cell viability decreased below 80%, while, at doses of 0.1 and 0.01 mg/mL, it remained around 90% thus, EO did not intervene in fibroblast proliferation, but it did influence fibroblast migration when wound-like was done in monolayer cultures. The results of this study demonstrated that the essential oil was a pro-wound-healing agent because it had good healing effectiveness with scars with good tensile strength and accelerated repair. The probable mechanism of action of the EO of B. morelensis, during the healing process, is the promotion of the migration of fibroblasts to the site of the wound, making them active in the production of collagen and promoting the remodeling of this collagen. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c13a619941e6ce085a8574552a36cf http://europepmc.org/articles/PMC7221833 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....45c13a619941e6ce085a8574552a36cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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