Selective Breeding for Divergence in Novelty-seeking Traits: Heritability and Enrichment in Spontaneous Anxiety-related Behaviors
| العنوان: | Selective Breeding for Divergence in Novelty-seeking Traits: Heritability and Enrichment in Spontaneous Anxiety-related Behaviors |
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| المؤلفون: | Abas Jama, Susan M. Miller, Delia M. Vazquez, Sarah M. Clinton, Charles R. Neal, Stanley J. Watson, Huda Akil, John D.H. Stead, Johanna Schneider |
| المصدر: | Behavior Genetics. 36:697-712 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Light, medicine.drug_class, Genetics, Behavioral, Anxiety, Breeding, Motor Activity, Anxiolytic, Open field, Chlordiazepoxide, Developmental psychology, Rats, Sprague-Dawley, Genetics, medicine, Animals, Humans, Maze Learning, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, Behavior, Animal, Reproduction, Novelty, Novelty seeking, Genetic Variation, Darkness, Heritability, medicine.disease, Rats, Substance abuse, Exploratory Behavior, medicine.symptom, Psychology, medicine.drug |
| الوصف: | Outbred Sprague-Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related to differential vulnerability to substance abuse, behavioral, neuroendocrine and gene expression studies suggest a fundamental difference in emotional reactivity between these animals. Here, we report the first study to selectively breed rats based on this novelty-seeking dimension. Response to novelty was clearly heritable, with a > 2-fold difference in behavior seen after eight generations of selection. Three tests of anxiety-like behavior consistently showed significantly greater anxiety in LR-bred rats compared to HR-bred animals, and this difference was diminished in the open field test by administration of the anxiolytic benzodiazepine drug, chlordiazepoxide. Cross-fostering revealed that responses to novelty were largely unaffected by maternal interactions, though there was an effect on anxiety-like behavior. These selected lines will enable future research on the interplay of genetic, environmental and developmental variables in controlling drug seeking behavior, stress and emotional reactivity. |
| تدمد: | 1573-3297 0001-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f7749d02345eee7a3f2339d0ca4d2d https://doi.org/10.1007/s10519-006-9058-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....45f7749d02345eee7a3f2339d0ca4d2d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15733297 00018244 |
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