Bee venom treatment reduced C-reactive protein and improved follicle quality in a rat model of estradiol valerate-induced polycystic ovarian syndrome
| العنوان: | Bee venom treatment reduced C-reactive protein and improved follicle quality in a rat model of estradiol valerate-induced polycystic ovarian syndrome |
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| المؤلفون: | Latifeh Karimzadeh, Saeed Irian, Mohamad Nabiuni, Azar Sheikholeslami |
| المصدر: | Journal of Venomous Animals and Toxins including Tropical Diseases v.18 n.4 2012 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 4, Pp 384-392 (2012) Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 18, Issue: 4, Pages: 384-392, Published: 2012 |
| بيانات النشر: | Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, endocrine system diseases, lcsh:RC955-962, media_common.quotation_subject, Toxicology, honeybee venom (HBV), Anovulation, corpus luteum, Follicle, lcsh:RA1190-1270, Internal medicine, lcsh:Zoology, medicine, lcsh:QL1-991, C-reactive protein (CRP), Ovulation, Testosterone, lcsh:Toxicology. Poisons, media_common, biology, C-reactive protein, Estradiol valerate, medicine.disease, female genital diseases and pregnancy complications, polycystic ovarian syndrome (PCOS), chemiluminescence immunoassay, Infectious Diseases, medicine.anatomical_structure, Endocrinology, Theca, biology.protein, estradiol valerate (EV), Animal Science and Zoology, Parasitology, Corpus luteum, medicine.drug |
| الوصف: | Polycystic ovarian syndrome (PCOS) is a low grade inflammatory disease characterized by hyperandrogenemia and chronic anovulation. C-reactive protein (CRP), released by adipocytes, plays a key role in PCOS. Apis mellifera honeybee venom (HBV) contains a variety of biologically active components with various pharmaceutical properties. This study was designed to assess the possibility of HBV application as an anti-inflammatory therapeutic agent. To induce PCOS, 1 mg/100 g body weight estradiol valerate (EV) was subcutaneously (SC) injected into eight-week-old rats. After 60 days, 0.5 mg/kg HBV was administered SC for 14 consecutive days, and the results of PCOS treatment were investigated. Rats were then anesthetized with chloroform, and their ovaries and livers were surgically removed to determine histomorphometrical changes. Testosterone and 17-β-estradiol were detected by chemiluminescence immunoassay. In order to detect serum CRP, ELISA kit was used in three groups of EV-induced PCOS, HBV-treated PCOS and control animals. Thickness of the theca layer, number of cysts and the level of serum CRP significantly decreased in HBV group in comparison with PCOS group. Moreover, corpus luteum, as a sign of ovulation, was observed in HBV-treated ovaries which were absent in PCOS group. Our results suggest that the beneficial effect of HBV may be mediated through its inhibitory effect on serum CRP levels. |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665ab4dbb67abe911d56f3fccecb22a http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400006 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4665ab4dbb67abe911d56f3fccecb22a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |