Surfactant Tracheobronchial Lavage for the Management of a Rabbit Model of Meconium Aspiration Syndrome
| العنوان: | Surfactant Tracheobronchial Lavage for the Management of a Rabbit Model of Meconium Aspiration Syndrome |
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| المؤلفون: | N.S. Tsoi, Chap-Yung Yeung, F.L. Chan, Barbara C.C. Lam, K.Y. Wong, K.H. Fu |
| المصدر: | Neonatology. 78:129-138 |
| بيانات النشر: | S. Karger AG, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Suction, Bronchoalveolar Lavage, Pulmonary surfactant, Meconium, Pregnancy, Meconium aspiration syndrome, Animals, Humans, Medicine, Lung, medicine.diagnostic_test, Inhalation, Pulmonary Gas Exchange, business.industry, Infant, Newborn, Pulmonary Surfactants, medicine.disease, Respiration, Artificial, Meconium Aspiration Syndrome, Radiography, Solutions, Trachea, Disease Models, Animal, Bronchoalveolar lavage, Lavage bronchoalveolaire, Anesthesia, Pediatrics, Perinatology and Child Health, Rabbit model, Female, Rabbits, Tracheobronchial lavage, business, Developmental Biology |
| الوصف: | We evaluated the effect of tracheobronchial lavage with diluted surfactant solution (bovine lipid extract surfactant, bLES) in a rabbit model of meconium aspiration. All animals were anaesthetized, tracheotomized and given 3–4 ml/kg of 25% slurry of human meconium into the endotracheal tube and mechanically ventilated for 1 h. The animals were then randomly assigned to surfactant lavage (n = 12) with 15 ml/kg of diluted surfactant at a concentration of 5.4 mg phospholipid/ml administered in aliquots of 2 ml; or simple endotracheal suction (control n = 12) when the oxygenation index (OI) was ≥15. Changes in the arterial blood gases and the histomorphological and radiological appearances of the lungs were recorded. The OI and arterial/alveolar oxygen tension (a/A PO2) of the surfactant lavage group improved significantly at 5 min post-treatment, and these improvements were observed throughout the ensuing 4 h of ventilation. There was significantly more solid content recovered by surfactant lavage compared with the control group (p = 0.0001). Radiologically, the post-treatment air space opacification scores of the lavage group were significantly lower compared with the control (p = 0.002). The post-treatment radiographs of the lavage-treated rabbits were rated by the radiologist, who was blinded to the treatment groups, as much improved in 5 and improved in 4, whereas the control rabbits were rated as much worse in 3 and worse in 4. Histological examination showed the lungs of the lavaged rabbits had significantly more normal airway (p < 0.0001), more fields showing completely normal airspace (p = 0.0001) and less fields showing severe overdistension with meconium (p = 0.0005). We concluded that lavage with diluted surfactant solution effectively washed out the meconium, improved gases exchanges, and improved the histological and radiological appearances in the rabbit model of MAS. |
| تدمد: | 1661-7819 1661-7800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46759bae41d985d5b874459d6a8f5532 https://doi.org/10.1159/000014261 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....46759bae41d985d5b874459d6a8f5532 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16617819 16617800 |
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