Developmental regulation of microtubule‐based trafficking and anchoring of axonal mitochondria in health and diseases
| العنوان: | Developmental regulation of microtubule‐based trafficking and anchoring of axonal mitochondria in health and diseases |
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| المؤلفون: | Zu-Hang Sheng, Xiu-Tang Cheng |
| المصدر: | Dev Neurobiol |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Biology, Mitochondrion, Microtubules, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Syntaphilin, Microtubule, medicine, Growth cone, Neurons, Regeneration (biology), Neurodegeneration, medicine.disease, Axons, Mitochondria, Cell biology, 030104 developmental biology, nervous system, Synapses, Axoplasmic transport, Energy source, 030217 neurology & neurosurgery |
| الوصف: | Mitochondria are cellular power plants that supply most of the ATP required in the brain to power neuronal growth, function, and regeneration. Given their extremely polarized structures and extended long axons, neurons face an exceptional challenge to maintain energy homeostasis in distal axons, synapses, and growth cones. Anchored mitochondria serve as local energy sources; therefore, the regulation of mitochondrial trafficking and anchoring ensures that these metabolically active areas are adequately supplied with ATP. Chronic mitochondrial dysfunction is a hallmark feature of major aging-related neurodegenerative diseases, and thus, anchored mitochondria in aging neurons need to be removed when they become dysfunctional. Investigations into the regulation of microtubule (MT)-based trafficking and anchoring of axonal mitochondria under physiological and pathological circumstances represent an important emerging area. In this short review article, we provide an updated overview of recent in vitro and in vivo studies showing (1) how mitochondria are transported and positioned in axons and synapses during neuronal developmental and maturation stages, and (2) how altered mitochondrial motility and axonal energy deficits in aging nervous systems link to neurodegeneration and regeneration in a disease or injury setting. We also highlight a major role of syntaphilin (SNPH) as a key MT-based regulator of axonal mitochondrial trafficking and anchoring in mature neurons. |
| تدمد: | 1932-846X 1932-8451 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46784076723e39e826bd01634380f41f https://doi.org/10.1002/dneu.22748 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....46784076723e39e826bd01634380f41f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1932846X 19328451 |
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