Genetic determinants of paediatric food allergy: A systematic review
| العنوان: | Genetic determinants of paediatric food allergy: A systematic review |
|---|---|
| المؤلفون: | Justine A. Ellis, Katrina J. Allen, Victoria X. Soriano, David Martino, Noor H. A. Suaini, Yichao Wang, Jennifer J. Koplin |
| المصدر: | Allergy. 74:1631-1648 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Candidate gene, DNA Copy Number Variations, Immunology, Peanut allergy, MEDLINE, Genome-wide association study, Filaggrin Proteins, Population stratification, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Food allergy, Environmental health, Odds Ratio, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Child, Alleles, Genetic Association Studies, Genetic association, business.industry, Age Factors, Odds ratio, medicine.disease, 030104 developmental biology, 030228 respiratory system, business, Food Hypersensitivity |
| الوصف: | Background The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. Methods We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018. Two authors screened retrieved articles for review according to inclusion criteria and extracted relevant information on study characteristics and measures of association. Eligible studies included those that reported an unaffected nonatopic control group, had genetic information and were carried out in children. Results Of the 2088 studies retrieved, 32 met our inclusion criteria. Five were genome-wide association studies, and the remaining were candidate gene studies. Twenty-two of the studies were carried out in a predominantly Caucasian population with the remaining 10 from Asian-specific populations or unspecified ethnicity. We found FLG, HLA, IL10, IL13, as well as some evidence for other variants (SPINK5, SERPINB and C11orf30) that are associated with food allergy. Conclusions Little genetic research has been carried out in food allergy, with FLG, HLA and IL13 being the most reproducible genes for an association with food allergy. Despite promising results, existing genetic studies on food allergy are inundated with issues such as inadequate sample size and absence of multiple testing correction. Few included replication analyses or population stratification measures. Studies addressing these limitations along with functional studies are therefore needed to unravel the mechanisms of action of the identified genes. |
| تدمد: | 1398-9995 0105-4538 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469be6cc1523c73a10f256cdfc63ac64 https://doi.org/10.1111/all.13767 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....469be6cc1523c73a10f256cdfc63ac64 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13989995 01054538 |
|---|