Preliminary Study Characterizing the Use of Sitagliptin for Glycemic Control in Healthy Beagle Dogs with Normal Gluco-Homeostasis
| العنوان: | Preliminary Study Characterizing the Use of Sitagliptin for Glycemic Control in Healthy Beagle Dogs with Normal Gluco-Homeostasis |
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| المؤلفون: | Toshiro Arai, Kaori Saeki, Toshinori Sako, Akihiro Mori, Hitomi Oda, Peter Lee |
| المصدر: | The Journal of Veterinary Medical Science |
| بيانات النشر: | Japanese Society of Veterinary Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Blood Glucose, insulin, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, canine, Pharmacology, Beagle, Sitagliptin Phosphate, Dogs, Glucagon-Like Peptide 1, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Animals, Homeostasis, Hypoglycemic Agents, Sitagliptin, glucose, Glycemic, GIP, General Veterinary, business.industry, Insulin, Type 2 Diabetes Mellitus, Triazoles, Note, medicine.disease, Glucagon-like peptide-1, Endocrinology, Gene Expression Regulation, Area Under Curve, Pyrazines, GLP-1, business, medicine.drug |
| الوصف: | Sitagliptin is a dipeptidyl peptidase-4 inhibitor aimed at treating Type 2 diabetes mellitus (T2DM) and T1DM, by increasing blood levels of Glucagon-like peptide 1 (GLP-1) and insulin. The objective of this preliminary study is to characterize Sitagliptin’s ability for glycemic control, in healthy dogs under an oral glucose tolerance test (OGTT) environment. Overall, Sitagliptin did not result in any significant changes to temporal glucose and insulin concentrations. However, a ~55% increase in median total GLP-1 AUC0–120min was observed, as compared to baseline control in healthy dogs (n=5), thus indicating a similar mode of action of Sitagliptin between healthy dogs and humans. Future studies to validate the use of Sitagliptin with dogs suffering from insulin independent diabetes are warranted. |
| تدمد: | 1347-7439 0916-7250 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46abcfc74dd6b9bd3cc87cafda92bf6f https://doi.org/10.1292/jvms.13-0590 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....46abcfc74dd6b9bd3cc87cafda92bf6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13477439 09167250 |
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