Nephroprotective, cytotoxic and antioxidant activities of Euphorbia paralias
| العنوان: | Nephroprotective, cytotoxic and antioxidant activities of Euphorbia paralias |
|---|---|
| المؤلفون: | Wagdi I.A. El-Dougdoug, Hanan M. Al-Yousef, Ali S Alqahtani, Afaf Said Ghani, Wafaa H.B. Hassan, Sayed A. El-Toumy, Hanaa M. Hassan |
| المصدر: | Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 785-792 (2021) Saudi Journal of Biological Sciences |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Euphorbia paralias, Antioxidant, Cytotoxic, DPPH, medicine.medical_treatment, Ethyl acetate, 01 natural sciences, Nephroprotective, Nephrotoxicity, 03 medical and health sciences, chemistry.chemical_compound, medicine, Gallic acid, lcsh:QH301-705.5, biology, Traditional medicine, biology.organism_classification, 030104 developmental biology, chemistry, lcsh:Biology (General), Polyphenol, Polyphenolic, Original Article, General Agricultural and Biological Sciences, 010606 plant biology & botany, Ellagic acid |
| الوصف: | Objective To investigate the effect of the ethyl acetate fraction of the aerial parts of E. paralias L. F. Euphorbiaceae on nephroprotective, cytotoxic, and antioxidant. Methods different spectroscopic and spectrophotometric methods were applied to identify phytoconstituents. The nephroprotective potential of E. paralias ethyl acetate fraction (Ep EtOAc) was evaluated in male rats with thioacetamide-induced kidney injury, as wll as cytotoxic activity was evaluated using a viability assay, and the antioxidant activity was evaluated using the DPPH method. Results: quantitative estimation of total phenolics and flavonoids of E. paralias was performed using unique spectrophotometric methods. The polyphenolic compounds gallic acid (1), ellagic acid (2), kaempferol-3-O-(6″-O-galloyl-β-D-glucopyranoside) (3), quercetin-3-O-β-D-glucopyranoside (4) and quercetin-3-O-β-D-arabinoside (5) were isolated from the ethyl acetate fraction of the aerial parts of E. paralias. The thioacetamide administration resulted in marked nephrotoxicity, but pretreatment with Ep EtOAc significantly attenuated the nephrotoxicity through alteration of kidney biomarkers, thereby improving the redox status of the tissue and restoring serum biochemical parameters nearly to normal levels. This study revealed a significant cytotoxic and strong antioxidant effect. Conclusion: we conclude that the Ep EtOAc may be used in the future as nephroprotective, cytotoxic, and antioxidant agent derived from a natural source. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ac7eeef35eba88ab9185e0e60e13c7 http://www.sciencedirect.com/science/article/pii/S1319562X20305738 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....46ac7eeef35eba88ab9185e0e60e13c7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |