Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era
| العنوان: | Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
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| المؤلفون: | Djaouida Bengoufa, L. Iordache, Alfred Mahr, Agathe Rami, Nesrine Day, Caroline Lascoux-Combe, Pierre-Olivier Sellier, Maguy Parrinello, Olivier Taulera, Jean-Michel Molina |
| المصدر: | Medicine |
| بيانات النشر: | Wolters Kluwer Health, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, HAART, Anti-nuclear antibody, autoantibodies, Observational Study, HIV Infections, antinuclear antibodies, Gastroenterology, Immunoglobulin G, 03 medical and health sciences, Antigen, Proteinase 3, immune system diseases, Internal medicine, Antiretroviral Therapy, Highly Active, medicine, Humans, Anti-neutrophil cytoplasmic antibody, biology, business.industry, Hypergammaglobulinemia, Autoantibody, HIV, General Medicine, Middle Aged, medicine.disease, 3. Good health, 030104 developmental biology, Cross-Sectional Studies, biology.protein, ANCAs, Female, Antibody, business, hypergammaglobulinemia, Research Article |
| الوصف: | Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm3, viral load |
| اللغة: | English |
| تدمد: | 1536-5964 0025-7974 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4750eaaec462c6d6f815c71255aa2b5d http://europepmc.org/articles/PMC5348164 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4750eaaec462c6d6f815c71255aa2b5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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