Effects of Glucose onfsr‐Mediated Biofilm Formation inEnterococcus faecalis
| العنوان: | Effects of Glucose onfsr‐Mediated Biofilm Formation inEnterococcus faecalis |
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| المؤلفون: | Satish K. Pillai, Roger T. Inouye, George Sakoulas, Barbara E. Murray, George M. Eliopoulos, Robert C. Moellering |
| المصدر: | The Journal of Infectious Diseases. 190:967-970 |
| بيانات النشر: | Oxford University Press (OUP), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Proteases, Biofilm, Proteolytic enzymes, Catabolite repression, Virulence, Gene Expression Regulation, Bacterial, biochemical phenomena, metabolism, and nutrition, Biology, biology.organism_classification, Enterococcus faecalis, Microbiology, Quorum sensing, Glucose, Infectious Diseases, Bacterial Proteins, Enterococcus, Biofilms, Endopeptidases, Mutation, Humans, Immunology and Allergy |
| الوصف: | Biofilm production is frequently dependent on such environmental factors as cell density and glucose concentration. The Enterococcus faecalis quorum-sensing locus (fsr) increases enterococcal virulence in multiple animal models. To date, fsr has been shown to regulate the transcription of 2 downstream protease genes. We demonstrate that the effect of fsr mutations on biofilm formation, as well as the fsr-mediated catabolite control of biofilm, is mediated via these proteases. The present study provides additional insight into the mechanisms used by E. faecalis to establish nosocomial infection. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4770a51b9e16823f6171c93f49156918 https://doi.org/10.1086/423139 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4770a51b9e16823f6171c93f49156918 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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