Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology
| العنوان: | Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology |
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| المؤلفون: | Claudia Vingerhoets, Elfi Vergaelen, Michael John Owen, Therese van Amelsvoort, Ann Swillen, Marianne Bernadette van den Bree, Samuel J.R.A. Chawner, Stefanie C. Linden, Sinead Morrison, David Edmund Johannes Linden |
| المساهمون: | RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), School for Mental Health & Neuroscience, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: MHeNs - R3 - Neuroscience, Academic Medical Center |
| المصدر: | Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020) Translational Psychiatry, 10(1):53. Nature Publishing Group Translational psychiatry, 10(1):53. Nature Publishing Group Translational Psychiatry |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Autism Spectrum Disorder, CHILDREN, Spatial memory, Cognition, 0302 clinical medicine, NEUROCOGNITIVE PROFILE, SCHIZOPHRENIA, Medicine, Child, Psychiatry, RISK, AUTISM SPECTRUM, Medical genetics, PSYCHIATRIC-DISORDERS, neurocognitive profile, Europe, Psychiatry and Mental health, Schizophrenia, Autism spectrum disorder, Life Sciences & Biomedicine, BEHAVIOR, Psychopathology, Clinical psychology, Adult, Adolescent, Article, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, PSYCHOSIS, Human behaviour, DiGeorge Syndrome, Humans, Attention deficit hyperactivity disorder, Cognitive Dysfunction, Cognitive skill, Effects of sleep deprivation on cognitive performance, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, Science & Technology, business.industry, behavior, medicine.disease, DUPLICATION, 030227 psychiatry, schizophrenia, INDIVIDUALS, business, 030217 neurology & neurosurgery |
| الوصف: | 22q11.2 Deletion Syndrome (22q11.2DS) is associated with high risk of psychiatric disorders and cognitive impairment. It remains unclear to what extent key cognitive skills are associated with psychopathology, and whether cognition is stable over time in 22q11.2DS. 236 children, adolescents and adults with 22q11.2DS and 106 typically developing controls were recruited from three sites across Europe. Measures of IQ, processing speed, sustained attention, spatial working memory and psychiatric assessments were completed. Cognitive performance in individuals was calculated relative to controls in different age groups (children (6-9 years), adolescents (10-17 years), adults (18+ years)). Individuals with 22q11.2DS exhibited cognitive impairment and higher rates of psychiatric disorders compared to typically developing controls. Presence of Autism Spectrum Disorder symptoms was associated with greater deficits in processing speed, sustained attention and working memory in adolescents but not children. Attention deficit hyperactivity disorder in children and adolescents and psychotic disorder in adulthood was associated with sustained attention impairment. Processing speed and working memory were more impaired in children and adults with 22q11.2DS respectively, whereas the deficit in sustained attention was present from childhood and remained static over developmental stages. Psychopathology was associated with cognitive profile of individuals with 22q11.2DS in an age-specific and domain-specific manner. Furthermore, magnitude of cognitive impairment differed by developmental stage in 22q11.2DS and the pattern differed by domain. ispartof: TRANSLATIONAL PSYCHIATRY vol:10 issue:1 ispartof: location:United States status: published |
| وصف الملف: | Electronic; application/pdf |
| اللغة: | English |
| تدمد: | 2158-3188 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4887bf3e844d956c7c46caedfe366cfe https://doi.org/10.1038/s41398-020-0736-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4887bf3e844d956c7c46caedfe366cfe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21583188 |
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