Higher Fecal Immunochemical Test Cutoff Levels: Lower Positivity Rates but Still Acceptable Detection Rates for Early-Stage Colorectal Cancers
| العنوان: | Higher Fecal Immunochemical Test Cutoff Levels: Lower Positivity Rates but Still Acceptable Detection Rates for Early-Stage Colorectal Cancers |
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| المؤلفون: | S.T. van Turenhout, A. A. Bouman, H. A. van Heukelem, J. S. Terhaar sive Droste, Cjj Mulder, Maarten Neerincx, Ruud J.L.F. Loffeld, R. W. M. Van Der Hulst, I. Ben Larbi, Frank A. Oort, Veerle M.H. Coupé, Shannon L. Kanis, Mirre Räkers, Gerrit A. Meijer |
| المساهمون: | Gastroenterology and hepatology, Medical oncology laboratory, Epidemiology and Data Science, Pathology, Clinical chemistry, CCA - Oncogenesis |
| المصدر: | Terhaar sive Droste, J S, Oort, F A, van der Hulst, R W M, Van Heukelem, H A, Loffeld, R J, van Turenhout, S T, Ben Larbi, I, Kanis, S L, Neerincx, M, Räkers, M, Coupé, V M H, Bouman, A A, Meijer, G A & Mulder, C J J 2011, ' Higher Fecal Immunochemical Test Cutoff Levels: Lower Positivity Rates but Still Acceptable Detection Rates for Early-Stage Colorectal Cancers ', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 2, pp. 272-280 . https://doi.org/10.1158/1055-9965.EPI-10-0848 Cancer Epidemiology Biomarkers and Prevention, 20(2), 272-280. American Association for Cancer Research Inc. |
| بيانات النشر: | American Association for Cancer Research (AACR), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, medicine.medical_specialty, Epidemiology, Population, Colonoscopy, Sensitivity and Specificity, Gastroenterology, Cohort Studies, Immunoenzyme Techniques, Feces, Predictive Value of Tests, Internal medicine, Spectrum bias, medicine, Humans, Mass Screening, Cutoff, Stage (cooking), education, Early Detection of Cancer, Aged, Neoplasm Staging, Aged, 80 and over, education.field_of_study, medicine.diagnostic_test, business.industry, Cancer, Middle Aged, medicine.disease, Surgery, Survival Rate, Oncology, Female, Detection rate, Colorectal Neoplasms, business, Follow-Up Studies |
| الوصف: | Background: Adjusting the threshold for positivity of quantitative fecal immunochemical tests (FIT) allows for controlling the number of follow-up colonoscopies in a screening program. However, it is unknown to what extent higher cutoff levels affect detection rates of screen-relevant neoplasia. This study aimed to assess the effect of higher cutoff levels of a quantitative FIT on test positivity rate and detection rate of early-stage colorectal cancers (CRC). Methods: Subjects above 40 years old scheduled for colonoscopy in 5 hospitals were asked to sample a single FIT (OC sensor) before colonoscopy. Screen-relevant neoplasia were defined as advanced adenoma or early-stage cancer (stage I and II). Positivity rate, sensitivity, and specificity were evaluated at increasing cutoff levels of 50 to 200 ng/mL. Results: In 2,145 individuals who underwent total colonoscopy, 79 patients were diagnosed with CRC, 38 of which were with early-stage disease. Advanced adenomas were found in 236 patients. When varying cutoff levels from ≥50 to ≥200 ng/mL, positivity rates ranged from 16.5% to 10.2%. With increasing cutoff levels, sensitivity for early-stage CRCs and for screen-relevant neoplasia ranged from 84.2% to 78.9% and 47.1% to 37.2%, respectively. Conclusions: Higher FIT cutoff levels substantially decrease test positivity rates with only limited effects on detection rates of early-stage CRCs. However, spectrum bias resulting in higher estimates of sensitivity than would be expected in a screening population may be present. Impact: Higher cutoff levels can reduce strain on colonoscopy capacity with only a modest decrease in sensitivity for curable cancers. Cancer Epidemiol Biomarkers Prev; 20(2); 272–80. ©2010 AACR. |
| تدمد: | 1538-7755 1055-9965 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4898e74e39cf5ca64d235bb00cc40f08 https://doi.org/10.1158/1055-9965.epi-10-0848 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4898e74e39cf5ca64d235bb00cc40f08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
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