Diastolic stiffness of the failing diabetic heart
| العنوان: | Diastolic stiffness of the failing diabetic heart |
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| المؤلفون: | Loek van Heerebeek, M. Louis Handoko, Casper G. Schalkwijk, Nazha Hamdani, Hans W.M. Niessen, Jolanda van der Velden, Koba Kupreishvili, Alexander Ijsselmuiden, Inês Falcão-Pires, Michaela Diamant, Ger J.M. Stienen, Attila Borbély, René J. P. Musters, Gerrit J Laarman, Jean G.F. Bronzwaer, Walter Paulus |
| المساهمون: | Physiology, Cardiology, Internal medicine, Pathology, Clinical chemistry, Human genetics, Laboratory Medicine, ICaR - Heartfailure and pulmonary arterial hypertension |
| المصدر: | van Heerebeek, L, Hamdani, N, Handoko, M L, Falcao-Pires, I, Musters, R J, Kupreishvili, K, Ijsselmuiden, A J J, Schalkwijk, C G, Bronzwaer, J G F, Diamant, M, Borbély, A, van der Velden, J, Stienen, G J M, Laarman, G J, Niessen, H W M & Paulus, W J 2008, ' Diastolic stiffness of the failing diabetic heart : importance of fibrosis, advanced glycation end products, and myocyte resting tension ', Circulation, vol. 117, no. 1, pp. 43-51 . https://doi.org/10.1161/CIRCULATIONAHA.107.728550 Circulation, 117(23). Lippincott Williams and Wilkins Circulation, 117(1), 43-51. Lippincott Williams and Wilkins Van Heerebeek, L, Hamdani, N, Handoko, M L, Falcao-Pires, I, Musters, R J, Borbely, A, Van Velden, J D, Stienen, G J M, Paulus, W J, Bronzwaer, J G F, Diamant, M, Kupreishvili, K, Niessen, H W M, Schalkwijk, C G, Ijsselmuiden, A J J & Laarman, G J 2008, ' Diastolic stiffness of the failing diabetic heart : Importance of fibrosis, advanced glycation end products. and myocyte resting tension ', Circulation, vol. 117, no. 23, pp. e484 . https://doi.org/10.1161/CIRCULATIONAHA.108.778167 |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Glycation End Products, Advanced, Male, medicine.medical_specialty, Heart disease, Heart Ventricles, Diastole, Coronary artery disease, Diabetes Complications, Physiology (medical), Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Myocytes, Cardiac, Elméleti orvostudományok, cardiovascular diseases, Heart Failure, Ejection fraction, business.industry, Stroke Volume, Stroke volume, Orvostudományok, Middle Aged, medicine.disease, Fibrosis, Cardiovascular physiology, Heart failure, Case-Control Studies, Muscle Tonus, Cardiology, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology |
| الوصف: | Background— Excessive diastolic left ventricular stiffness is an important contributor to heart failure in patients with diabetes mellitus. Diabetes is presumed to increase stiffness through myocardial deposition of collagen and advanced glycation end products (AGEs). Cardiomyocyte resting tension also elevates stiffness, especially in heart failure with normal left ventricular ejection fraction (LVEF). The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF. Methods and Results— Left ventricular endomyocardial biopsy samples were procured in 28 patients with normal LVEF and 36 patients with reduced LVEF, all without coronary artery disease. Sixteen patients with normal LVEF and 10 with reduced LVEF had diabetes mellitus. Biopsy samples were used for quantification of collagen and AGEs and for isolation of cardiomyocytes to measure resting tension. Diabetic heart failure patients had higher diastolic left ventricular stiffness irrespective of LVEF. Diabetes mellitus increased the myocardial collagen volume fraction only in patients with reduced LVEF (from 14.6±1.0% to 22.4±2.2%, P 2 , P =0.006). Diabetes increased myocardial AGE deposition in patients with reduced LVEF (from 8.8±2.5 to 24.1±3.8 score/mm 2 ; P =0.005) and less so in patients with normal LVEF (from 8.2±2.5 to 15.7±2.7 score/mm 2 , P =NS). Conclusions— Mechanisms responsible for the increased diastolic stiffness of the diabetic heart differ in heart failure with reduced and normal LVEF: Fibrosis and AGEs are more important when LVEF is reduced, whereas cardiomyocyte resting tension is more important when LVEF is normal. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0009-7322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a9db7d844992dffa47c0e39bde853c https://doi.org/10.1161/circulationaha.107.728550 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....48a9db7d844992dffa47c0e39bde853c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00097322 |
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