The concentration of programmed cell death-ligand 1 in the peripheral blood is a useful biomarker for esophageal squamous cell carcinoma
| العنوان: | The concentration of programmed cell death-ligand 1 in the peripheral blood is a useful biomarker for esophageal squamous cell carcinoma |
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| المؤلفون: | Hisahiro Matsubara, Masaya Yokoyama, Masayuki Kano, Kentaro Murakami, Yasunori Matsumoto, Takeshi Toyozumi, Tadashi Shiraishi, Yasunori Akutsu, Nobufumi Sekino, Ryota Otsuka, Masahiko Takahashi |
| المصدر: | Esophagus. 15:103-108 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Esophageal Neoplasms, Programmed Cell Death 1 Receptor, Gastroenterology, B7-H1 Antigen, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Surgical oncology, Internal medicine, medicine, Humans, Neoplasm Invasiveness, Stage (cooking), Lymph node, Aged, Neoplasm Staging, business.industry, Middle Aged, Esophageal cancer, Programmed Cell Death 1 Ligand 2 Protein, medicine.disease, Survival Rate, 030104 developmental biology, medicine.anatomical_structure, Tumor progression, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Disease Progression, Biomarker (medicine), Female, Lymph, business, Biomarkers |
| الوصف: | We determined the serum concentrations of Programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2) in patients with esophageal squamous cell carcinoma (ESCC). Blood samples were collected from 85 patients with histologically proved ESCC. Serum levels of PD-1, PD-L1, and PD-L2 were measured using enzyme linked immunosorbent assays. Correlations between serum PD-1, PD-L1, and PD-L2 concentration and tumor depth, number of lymph node metastases, organ metastasis status, or disease stage were assessed and five-year survival rates according to clinicopathological characteristics were calculated. The concentration of PD-1 was not differed according to tumor progression. On the other hand, the average concentration of PD-L1 in patients with T3/T4 disease was 15.6 (12.2–18.3) pg/mL (25–75%), and this was significantly higher than that in patients with Tis/T1/T2 disease (p = 0.020). Similarly, PD-L1 levels were significantly higher in patients with positive lymph nodes than in cases with negative lymph node involvement (p = 0.006) and were higher in patients with organ metastasis (p = 0.123) and in more advanced stage (p = 0.006). Similar tendency was observed regarding PD-L2 concentrations. PD-L2 concentration was higher in T3, T4 cases (p = 0.008), in LN positive cases (p = 0.032), and in more advanced stage (p = 0.024). Our data showed that a concentration of PD-L1 in peripheral blood was high in advanced cancer and high concentration of PD-L1 predicted disease progression and also poor survival in patients with ESCC. |
| تدمد: | 1612-9067 1612-9059 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49526455f545f78dbebbea7c79bada23 https://doi.org/10.1007/s10388-018-0604-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....49526455f545f78dbebbea7c79bada23 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16129067 16129059 |
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