The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children
| العنوان: | The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children |
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| المؤلفون: | John D. Doyle, Marc Ansari, Jean-Marie Tiercy, Tal Schechter, Chakradhara Rao S. Uppugunduri, Fabienne Gumy-Pause, L. Lee Dupuis, Adam Gassas, Michel Duval, Jean Villard, Maja Krajinovic, Yves Chalandon, Henrique Bittencourt, Sylvie Ferrari-Lacraz |
| المصدر: | PLOS ONE, Vol. 8, No 8 (2013) P. e72141 PLoS ONE, Vol 8, Iss 8, p e72141 (2013) PLoS ONE Scopus-Elsevier |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Anatomy and Physiology, medicine.medical_treatment, Graft vs Host Disease, Kaplan-Meier Estimate, Hematopoietic stem cell transplantation, Pediatrics, Immune Physiology, Bone Marrow and Stem Cell Transplantation, Child, health care economics and organizations, ddc:616, Multidisciplinary, ddc:618, Hematopoietic Stem Cell Transplantation, Antibody titer, Hematology, Clinical Laboratory Sciences, Leukemia, Myeloid, Acute, Leukemia, Treatment Outcome, Child, Preschool, Cord blood, Medicine, Female, Cord Blood Stem Cell Transplantation, Research Article, Adolescent, Science, Immunology, Antibodies, Disease-Free Survival, Young Adult, Antigen, Diagnostic Medicine, medicine, Humans, Pediatric Hematology, Biology, Autoantibodies, Retrospective Studies, HLA-A Antigens, business.industry, Infant, medicine.disease, HLA Mismatch, Transplantation, Myelodysplastic Syndromes, Clinical Immunology, business |
| الوصف: | Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1–4 acute graft-versus host disease (p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a5947601d2d01cc5941a85b3897784 https://archive-ouverte.unige.ch/unige:35602 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....49a5947601d2d01cc5941a85b3897784 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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