Serum soluble lymphocyte activation gene‐3 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study
| العنوان: | Serum soluble lymphocyte activation gene‐3 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study |
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| المؤلفون: | Gang Wang, Gen Li, Sheng-Di Chen, Shi-Shuang Cui, Pingchen Zhang, Yi-Xi He, Yi-Qi Lin, Juan-Juan Du, Shi‐Hua Liu, Jie Meng |
| المصدر: | Movement Disorders. 34:138-141 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, Essential Tremor, Disease, Lymphocyte Activation, Gastroenterology, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, Internal medicine, medicine, Humans, Pathological, Essential tremor, business.industry, Neurodegeneration, Area under the curve, Parkinson Disease, Middle Aged, medicine.disease, Lymphocyte Activation Gene 3 Protein, Phenotype, 030104 developmental biology, Neurology, Biomarker (medicine), Female, Neurology (clinical), business, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Objective Lymphocyte activation gene-3 (LAG-3) could mediate pathological α-synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG-3 (sLAG-3) as a potential diagnostic biomarker for PD. Methods Serum sLAG-3 concentrations were measured by a quantitative ELISA for patients with PD, essential tremor (ET) and age- and sex-matched controls. The relationships between sLAG-3 and clinical phenotype were assessed via correlation analysis and logistic regression. Results Serum sLAG-3 levels in patients with PD were significantly higher than those in ET patients and age- and sex-matched controls. The area under the curve of serum sLAG-3 in differentiating PD from age- and sex-matched controls was 0.82. Serum sLAG-3 was associated with non-motor symptoms and excessive daytime sleep. Conclusion sLAG-3 is a candidate novel biomarker for PD. © 2018 International Parkinson and Movement Disorder Society. |
| تدمد: | 1531-8257 0885-3185 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dd4c5c1c87ffdffd96285af9ec4a7b https://doi.org/10.1002/mds.27569 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....49dd4c5c1c87ffdffd96285af9ec4a7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318257 08853185 |
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