Bacterial quorum‐sensing signal IQS induces host cell apoptosis by targeting POT1–p53 signalling pathway
| العنوان: | Bacterial quorum‐sensing signal IQS induces host cell apoptosis by targeting POT1–p53 signalling pathway |
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| المؤلفون: | Chao Wang, Shumei Lv, Lian-Hui Zhang, Wang Jianhe, Hong‐Bing Yu, Stephen Dela Ahator, Wu Xiaoyan |
| المصدر: | Cellular Microbiology. 21 |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cell Survival, DNA damage, Telomere-Binding Proteins, Immunology, Virulence, Apoptosis, Biology, medicine.disease_cause, Microbiology, Shelterin Complex, Pathogenesis, Mice, 03 medical and health sciences, Bacterial Proteins, Phenols, Virology, medicine, Animals, Humans, Pseudomonas Infections, Pathogen, Cell Proliferation, 030304 developmental biology, 0303 health sciences, 030306 microbiology, Pseudomonas aeruginosa, Quorum Sensing, Hedgehog signaling pathway, Cell biology, Checkpoint Kinase 2, Thiazoles, Quorum sensing, A549 Cells, Checkpoint Kinase 1, Proteolysis, Tumor Suppressor Protein p53, DNA Damage |
| الوصف: | Pseudomonas aeruginosa, an opportunistic life-threatening human bacterial pathogen, employs quorum-sensing (QS) signal molecules to modulate virulence gene expression. 2-(2-hydroxyphenyl)-thiazole-4-carbaldehyde (IQS) is a recently identified QS signal that integrates the canonical lasR-type QS of P. aeruginosa and host phosphate stress response to fine-tune its virulence production for a successful infection. To address the role of IQS in pathogen-host interaction, we here present that IQS inhibits host cell growth and stimulates apoptosis in a dosage-dependent manner. By downregulating the telomere-protecting protein POT1 in host cells, IQS activates CHK1, CHK2, and p53 in an Ataxia telangiectasia mutated (ATM)/ATM and RAD3-related (ATR)-dependent manner and induces DNA damage response. Overexpression of POT1 in host cells presents a resistance to IQS treatment. These results suggest a pivotal role of IQS in host apoptosis, highlighting the complexity of pathogenesis mechanisms developed by P. aeruginosa during infection. |
| تدمد: | 1462-5822 1462-5814 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1c57864ea76a5ecb979b35d5def68b https://doi.org/10.1111/cmi.13076 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4a1c57864ea76a5ecb979b35d5def68b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14625822 14625814 |
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