Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy
| العنوان: | Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy |
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| المؤلفون: | Shyuichiro Matsubara, Qiang Ding, Sonshin Takao |
| المصدر: | Journal of Hepato-Biliary-Pancreatic Sciences. 19:614-620 |
| بيانات النشر: | Wiley, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, medicine.medical_treatment, Cell- and Tissue-Based Therapy, Targeted therapy, Surgical oncology, Cancer stem cell, Pancreatic cancer, Internal medicine, Biomarkers, Tumor, Tumor Microenvironment, medicine, Humans, Solid tumor, Tumor microenvironment, Hepatology, business.industry, Cancer, DNA, Neoplasm, medicine.disease, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Disease Progression, Neoplastic Stem Cells, Surgery, Stem cell, business |
| الوصف: | Recent evidence has demonstrated that the existence of a cancer stem cell (CSC) subset in a solid tumor is responsible for the progression and relapse of cancer as well as its resistance to current therapies. Over the past decade, CSC research on pancreatic cancer has progressed. A fundamental understanding of pancreatic CSCs may improve therapies and deepen insight into the role of cell-cell interactions within a tumor microenvironment in pancreatic cancer progression. This review focuses on the impact of pancreatic CSCs on the regulatory networks in the tumor microenvironment, and the implications of targeting CSCs to treat pancreatic cancer. |
| تدمد: | 1868-6982 1868-6974 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a31a07166d18636aa0ff4755e6b46b1 https://doi.org/10.1007/s00534-012-0547-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4a31a07166d18636aa0ff4755e6b46b1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18686982 18686974 |
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