Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway
| العنوان: | Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway |
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| المؤلفون: | Jin-Wei Xue, Yun-fei Wang, Ligang Qian, Qiao Ren, Zheng Ma, Zhixing Liang, Taoping Chen, Yuan-Tao Jiang, Bo Sun, Yu Hou, Kang Chen, Jianbao Jiao |
| المصدر: | Oncology Reports |
| بيانات النشر: | D.A. Spandidos, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Ginsenosides, Cell Survival, proliferation, Cell, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Annexin, Cell Movement, Cell Line, Tumor, medicine, Humans, Neoplasm Invasiveness, PI3K/AKT/mTOR pathway, Cell Proliferation, Osteosarcoma, Oncogene, Chemistry, TOR Serine-Threonine Kinases, apoptosis, Ribosomal Protein S6 Kinases, 70-kDa, General Medicine, Articles, Cell cycle, medicine.disease, invasion, ginsenoside CK, 030104 developmental biology, medicine.anatomical_structure, Oncology, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction |
| الوصف: | Osteosarcoma is one of the most malignant bone tumors, and its major threats are aggressive invasion and early tumor metastasis, which result in a poor prognosis and high mortality. Accumulating evidence indicates that ginsenoside compound K (CK) has a significant antitumor effect, particularly on the inhibition of proliferation and invasion of numerous human tumors. In the present study, it was revealed that CK inhibited the viability and proliferation of osteosarcoma cells. Moreover, it was demonstrated that CK induced apoptosis and inhibited the migration and invasion of osteosarcoma cells via apoptotic staining, Annexin V/PI staining, and Transwell invasion assays. Furthermore, at the molecular level, the present results confirmed that apoptosis and invasion‑related proteins were regulated by CK, which was possibly related to the blockade of the PI3K/mTOR/p70S6K1 signaling pathway. In summary, the present findings indicated that CK inhibited viability and proliferation, induced apoptosis, and inhibited the migration and invasion of osteosarcoma cells through the PI3K/mTOR/p70S6K1 signaling pathway. |
| اللغة: | English |
| تدمد: | 1791-2431 1021-335X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a33164e1c406c7f5652aa53baf711d5 http://europepmc.org/articles/PMC7041301 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4a33164e1c406c7f5652aa53baf711d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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