Hypertonic sodium lactate reverses brain oxygenation and metabolism dysfunction after traumatic brain injury
| العنوان: | Hypertonic sodium lactate reverses brain oxygenation and metabolism dysfunction after traumatic brain injury |
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| المؤلفون: | Thibaud Crespy, Adrien Cuisinier, Karin Pernet-Gallay, Jean-François Payen, Benjamin Lemasson, Cécile Batandier, Emmanuel L. Barbier, Vasile Stupar, Anne Millet, Pierre Bouzat |
| المساهمون: | Centre Hospitalier Universitaire [Grenoble] (CHU), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| المصدر: | British Journal of Anaesthesia British Journal of Anaesthesia, Oxford University Press (OUP), 2018, 120 (6), pp.1295-1303. ⟨10.1016/j.bja.2018.01.025⟩ |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Traumatic brain injury, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Brain Edema, Creatine, Sodium Lactate, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oxygen Consumption, Internal medicine, Brain Injuries, Traumatic, Sodium lactate, Medicine, Animals, Rats, Wistar, Saline, ComputingMilieux_MISCELLANEOUS, Cerebral Cortex, Saline Solution, Hypertonic, medicine.diagnostic_test, business.industry, food and beverages, Brain, 030208 emergency & critical care medicine, Magnetic resonance imaging, Oxygenation, medicine.disease, Mitochondria, Disease Models, Animal, Microscopy, Electron, Anesthesiology and Pain Medicine, Endocrinology, chemistry, Tonicity, Fluid Therapy, business, Perfusion, 030217 neurology & neurosurgery |
| الوصف: | Background The mechanisms by which hypertonic sodium lactate (HSL) solution act in injured brain are unclear. We investigated the effects of HSL on brain metabolism, oxygenation, and perfusion in a rodent model of diffuse traumatic brain injury (TBI). Methods Thirty minutes after trauma, anaesthetised adult rats were randomly assigned to receive a 3 h infusion of either a saline solution (TBI–saline group) or HSL (TBI–HSL group). The sham–saline and sham–HSL groups received no insult. Three series of experiments were conducted up to 4 h after TBI (or equivalent) to investigate: 1) brain oedema using diffusion-weighted magnetic resonance imaging and brain metabolism using localized 1 H-magnetic resonance spectroscopy ( n = 10 rats per group). The respiratory control ratio was then determined using oxygraphic analysis of extracted mitochondria, 2) brain oxygenation and perfusion using quantitative blood-oxygenation-level-dependent magnetic resonance approach ( n = 10 rats per group), and 3) mitochondrial ultrastructural changes ( n = 1 rat per group). Results Compared with the TBI–saline group, the TBI–HSL and the sham-operated groups had reduced brain oedema. Concomitantly, the TBI–HSL group had lower intracellular lactate/creatine ratio [0.049 (0.047–0.098) vs 0.097 (0.079–0.157); P vs 66% (55–73); P vs 38.4 (31.0–47.5) nm; P Conclusions These findings indicate that the hypertonic sodium lactate solution can reverse brain oxygenation and metabolism dysfunction after traumatic brain injury through vasodilatory, mitochondrial, and anti-oedema effects. |
| تدمد: | 1471-6771 0007-0912 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9221a2d6c97945fadd39cb430edac5 https://pubmed.ncbi.nlm.nih.gov/29793596 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4a9221a2d6c97945fadd39cb430edac5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14716771 00070912 |
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