Multistage Systemic and Cytosolic Protein Delivery for Effective Cancer Treatment
| العنوان: | Multistage Systemic and Cytosolic Protein Delivery for Effective Cancer Treatment |
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| المؤلفون: | Liyi Fu, Xianwu Hua, Xingya Jiang, Jinjun Shi |
| المصدر: | Nano Letters. 22:111-118 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Drug Delivery Systems, Polymers, Cell Line, Tumor, Neoplasms, Mechanical Engineering, Tumor Microenvironment, Humans, Nanoparticles, General Materials Science, Bioengineering, General Chemistry, Condensed Matter Physics |
| الوصف: | Current clinical applications of protein therapy are largely limited to systemically accessible targets in vascular or extracellular areas. Major obstacles to the widespread application of protein therapeutics in cancer treatment include low membrane permeability and endosomal entrapment. Herein, we report a multistage nanoparticle (NP) strategy for systemic and cytosolic protein delivery to tumor cells, by encapsulating a protein conjugate, tetra-guanidinium (TG)-modified saporin, into tumor microenvironment (TME) pH-responsive polymeric NPs. Upon reaching the tumor site after systemic circulation, the polymeric NPs respond rapidly to the acidic tumor microenvironment and release the TG-saporin conjugates, which penetrate the tumor tissue and enter into tumor cells via TG-mediated cytosolic transportation. The TG-saproin NPs showed potent inhibition of lung cancer cell growth in vitro and in vivo. We expect that this multistage NP delivery strategy with long blood circulation, deep tumor penetration, and efficient cytosolic transport may be applicable to various therapeutic proteins for effective cancer treatment. |
| تدمد: | 1530-6992 1530-6984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aedd7f852c9dc551c77cee3a986255c https://doi.org/10.1021/acs.nanolett.1c03293 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4aedd7f852c9dc551c77cee3a986255c |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15306992 15306984 |
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