In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment
| العنوان: | In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment |
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| المؤلفون: | Yukihiko Kubota, Tetsuya Inazu, Muhamad Fahmi, Masahiro Ito, Syouichi Katayama, Takako Kaneko-Kawano, Kaito Seki, Gen Yasui |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 22, p 5593 (2019) International Journal of Molecular Sciences Volume 20 Issue 22 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, In silico, CDKL5, Rett syndrome, Computational biology, Biology, Catalysis, MECP2, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Neurodevelopmental disorder, forkhead box protein g1, medicine, Physical and Theoretical Chemistry, Molecular Biology, rett syndrome, lcsh:QH301-705.5, Spectroscopy, post-transcriptional modification, Organic Chemistry, General Medicine, medicine.disease, intrinsically disordered region, cyclin-dependent kinase-like 5, Computer Science Applications, FOXG1, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Phylogenetic profiling, phylogenetic profile analysis, 030217 neurology & neurosurgery, methyl-cpg-binding protein 2, Forkhead Box Protein G1 |
| الوصف: | Rett syndrome (RTT), a neurodevelopmental disorder, is mainly caused by mutations in methyl CpG-binding protein 2 (MECP2), which has multiple functions such as binding to methylated DNA or interacting with a transcriptional co-repressor complex. It has been established that alterations in cyclin-dependent kinase-like 5 (CDKL5) or forkhead box protein G1 (FOXG1) correspond to distinct neurodevelopmental disorders, given that a series of studies have indicated that RTT is also caused by alterations in either one of these genes. We investigated the evolution and molecular features of MeCP2, CDKL5, and FOXG1 and their binding partners using phylogenetic profiling to gain a better understanding of their similarities. We also predicted the structural order&ndash disorder propensity and assessed the evolutionary rates per site of MeCP2, CDKL5, and FOXG1 to investigate the relationships between disordered structure and other related properties with RTT. Here, we provide insight to the structural characteristics, evolution and interaction landscapes of those three proteins. We also uncovered the disordered structure properties and evolution of those proteins which may provide valuable information for the development of therapeutic strategies of RTT. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b107a8351882b952e1f772ea5a5c272 https://www.mdpi.com/1422-0067/20/22/5593 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4b107a8351882b952e1f772ea5a5c272 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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