Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications
| العنوان: | Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications |
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| المؤلفون: | Charles Hu, Dara L. Kraitchman, Clifford R. Weiss, Cyrus W. Beh, Hai-Quan Mao, Tza-Huei Wang, Aravind Arepally, Yingli Fu |
| المصدر: | Lab Chip |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Materials science, Alginates, Swine, Radiodensity, medicine.medical_treatment, Microfluidics, Dispersity, Biomedical Engineering, Bioengineering, Biochemistry, Article, 030218 nuclear medicine & medical imaging, Microsphere, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Embolization, X-Rays, Arterial Embolization, X-ray, Washout, General Chemistry, Embolization, Therapeutic, Microspheres, 030220 oncology & carcinogenesis, Biomedical engineering |
| الوصف: | Embolotherapy using particle embolics is normally performed with exogenous contrast to assist in visualization. However, the exact location of the embolics cannot be identified after contrast washout. We developed a novel, pseudo-check valve-integrated microfluidic device, that partitions barium- impregnated alginate from crosslinking solution, thereby preventing nozzle failure. This enables rapid and continuous generation of inherently X-ray-visible embolic microspheres (XEMs) with uniform size. The XEMs are visible under clinical X-ray and cone beam CT both in vitro and in vivo. In particular, we demonstrated the embolization properties of these XEMs in large animals, performing direct intra- and post-procedural assessment of embolic delivery. The persistent radiopacity of these XEMs enables real-time evaluation of embolization precision and offers great promise for non-invasive follow-up examination without exogenous contrast. We also demonstrated that bariatric arterial embolization with XEMs significantly suppresses weight gain in swine, as an example of a non-oncological application of embolotherapy. |
| تدمد: | 1473-0189 1473-0197 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b316ffa20f2edccfcca2d4d91a44fd2 https://doi.org/10.1039/d0lc00098a |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4b316ffa20f2edccfcca2d4d91a44fd2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14730189 14730197 |
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