Inhibition of dengue virus replication by amantadine hydrochloride
| العنوان: | Inhibition of dengue virus replication by amantadine hydrochloride |
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| المؤلفون: | Wayne C. Koff, Joe L. Elm, Scott B. Halstead |
| المصدر: | Antimicrobial Agents and Chemotherapy. 18:125-129 |
| بيانات النشر: | American Society for Microbiology, 1980. |
| سنة النشر: | 1980 |
| مصطلحات موضوعية: | Time Factors, viruses, Amantadine Hydrochloride, Biology, Dengue virus, Virus Replication, medicine.disease_cause, Virus, Dengue fever, Microbiology, Dengue, In vivo, Amantadine, Leukocytes, medicine, Animals, Humans, Pharmacology (medical), Cytopathic effect, Pharmacology, Dose-Response Relationship, Drug, Dengue Virus, medicine.disease, Macaca mulatta, Virology, Infectious Diseases, Viral replication, Research Article, medicine.drug |
| الوصف: | The effect of amantadine hydrochloride (1-adamantanamine hydrochloride) on dengue virus replication was examined in vitro. Amantadine decreased the titers of all four types of dengue viruses grown in LLC-MK2 cells by greater than 90% at concentrations of 50 micrograms/ml. There was no evidence for any cytopathic effect of the drug at concentrations less than 100 micrograms/ml. Studies of the time of addition showed that the antiviral effect was maximal when drug was added to virus cultures immediately after the viral adsorption period. In addition, amantadine caused a marked reduction in the growth of dengue virus type 2 in both human and rhesus peripheral blood leukocytes without affecting cell viabili ty. These findings demonstrate that amantadine significantly inhibits the replication of dengue viruses in vitro and indicate a need to determine the efficacy of this drug against dengue virus infections in vivo. |
| تدمد: | 1098-6596 0066-4804 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4114f24d8138563180e77186f6979c https://doi.org/10.1128/aac.18.1.125 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4b4114f24d8138563180e77186f6979c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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