The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages.: IL4I1 expression in human tumors
| العنوان: | The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages.: IL4I1 expression in human tumors |
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| المؤلفون: | Flavia Castellano, Philippe Gaulard, Maryse Baia, Corinne Haioun, Valérie Molinier-Frenkel, Christiane Copie-Bergman, Jean-Pierre Farcet, Issam Abd-Alsamad, Nadine Martin-Garcia, Yves Allory, Amélie Carbonnelle-Puscian, Anne Cremades |
| المساهمون: | Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Service d'hématologie clinique, Service d'Anatomo-Pathologie, CHI Créteil, Service d'immunologie biologique, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) |
| المصدر: | Leukemia Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2009, 23 (5), pp.952-60. ⟨10.1038/leu.2008.380⟩ Leukemia, Springer Nature, 2009, 23 (5), pp.952-60. ⟨10.1038/leu.2008.380⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, medicine.medical_specialty, Lymphoma, B-Cell, tumour-associated macrophages, Lymphocyte, Follicular lymphoma, lymphoma, Enzyme-Linked Immunosorbent Assay, Tumor-associated macrophage, Biology, L-Amino Acid Oxidase, Article, Cohort Studies, Immunoenzyme Techniques, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Tumor Cells, Cultured, medicine, cancer, Humans, Cytotoxic T cell, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, B cell, 030304 developmental biology, B-Lymphocytes, 0303 health sciences, immunosuppression, Macrophages, Germinal center, Hematology, Middle Aged, myeloid-derived suppressor cells, Germinal Center, Neoplastic Cells, Circulating, medicine.disease, 3. Good health, Lymphoma, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Myeloid-derived Suppressor Cell, Cancer research, Female |
| الوصف: | International audience; We previously reported a strong IL4I1 gene expression in primary mediastinal B-cell lymphoma (PMBL) and recently identified the protein as a secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, which inhibits T-cell proliferation in vitro. Here, we analyzed the pattern of IL4I1 protein expression in 315 human lymphoid and non-lymphoid malignancies. Besides PMBL, IL4I1 expression in tumors was very frequent. IL4I1 was detected in tumor-associated macrophages from most of the tumors and in neoplastic cells from follicular lymphoma, classic and nodular lymphocyte predominant Hodgkin lymphomas and small lymphocytic lymphoma, three of which are germinal center derived. IL4I1-positive tumor cells were also detected in rare cases of solid cancers, mainly mesothelioma. The enzymatic activity paralleled protein expression, suggesting that IL4I1 is functional in vivo. Depending on the tumor type, IL4I1 may impact on different infiltrating lymphocyte populations with consequences on tumor evolution. In the particular case of follicular lymphoma cells, which are susceptible to antitumor cytotoxic T cells killing but depend on interactions with local T helper cells for survival, a high level of IL4I1 expression seems associated with the absence of bone marrow involvement and a better outcome. These findings plead for an evaluation of IL4I1 as a prognosis factor. |
| تدمد: | 1476-5551 0887-6924 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b62f9f4dd12f0c44edbb4b90593ba99 https://doi.org/10.1038/leu.2008.380 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4b62f9f4dd12f0c44edbb4b90593ba99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765551 08876924 |
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