Obesity and chronic kidney disease progression—the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1
| العنوان: | Obesity and chronic kidney disease progression—the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1 |
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| المؤلفون: | Eduardo Verde, Maria Dolores Sanchez-Niño, José Luño, Nieves Lopez Lazareno, Alberto Ortiz, Esther Hurtado, Marian Goicoechea, Luis Sanchez-Cámara, Andrés Delgado, Ursula Verdalles, Ana García-Prieto, Diego Barbieri, Ana Pérez de José |
| المصدر: | Clinical Kidney Journal Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | obesity, medicine.medical_specialty, medicine.medical_treatment, Population, 030232 urology & nephrology, Renal function, urologic and male genital diseases, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Diabetes mellitus, CKD, Medicine, education, Dialysis, Transplantation, Creatinine, education.field_of_study, Kidney, adipokine, business.industry, medicine.disease, medicine.anatomical_structure, chemistry, Nephrology, Albuminuria, progression, medicine.symptom, CTRP1, business, chronic kidney disease, Kidney disease |
| الوصف: | Background Obesity is a risk factor for incident chronic kidney disease (CKD) in the general population. C1q/tumour necrosis factor-related protein 1 (CTRP1) is a new adipokine with multiple vascular and metabolic effects and may modulate the association between obesity and vascular diseases. The aim of the study is to explore potential links between obesity, CTRP1 levels and CKD progression. Methods Patients with Stages 3 and 4 CKD without previous cardiovascular events were enrolled and divided into two groups according to body mass index (BMI). Demographic, clinical and analytical data and CTRP1 levels were collected at baseline. During follow-up, renal events [defined as dialysis initiation, serum creatinine doubling or a 50% decrease in estimated glomerular filtration rate (Modification of Diet in Renal Disease)] were registered. Results A total of 71 patients with CKD were divided into two groups: 25 obese (BMI >30 kg/m2) and 46 non-obese. CTRP1 in plasma at baseline was higher in obese patients [median (interquartile range) 360 (148) versus 288 (188) ng/mL, P = 0.041]. No significant association was found between CTRP1 levels and CKD stage, presence of diabetes, aldosterone and renin levels, or blood pressure. Obese patients had higher systolic blood pressure (P = 0.018) and higher high-sensitivity C-reactive protein (P = 0.019) and uric acid (P = 0.003) levels, without significant differences in the percentage of diabetic patients or albuminuria. During a mean follow-up of 65 months, 14 patients had a renal event. Patients with CTRP1 in the lowest tertile had more renal events, both in the overall sample (log rank: 5.810, P = 0.016) and among obese patients (log rank: 5.405, P = 0.020). Higher CTRP1 levels were associated with slower renal progression (hazard ratio 0.992, 95% confidence interval 0.986–0.998; P = 0.001) in a model adjusted for obesity, aspirin, albuminuria and renal function. Conclusions CTRP1 levels are higher in obese than in non-obese patients with CKD. High CTRP1 levels may have a renal protective role since they were associated with slower kidney disease progression. Interventional studies are needed to explore this hypothesis. |
| وصف الملف: | application/pdf |
| تدمد: | 2048-8513 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9cdb64a08fd573975e10c069e3204a https://doi.org/10.1093/ckj/sfy095 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4b9cdb64a08fd573975e10c069e3204a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488513 |
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