High prevalence of intermediate-risk human papillomavirus infection in uterine cervices of kenyan women infected with human immunodeficiency virus
| العنوان: | High prevalence of intermediate-risk human papillomavirus infection in uterine cervices of kenyan women infected with human immunodeficiency virus |
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| المؤلفون: | Rika Yamada, Toshiyuki Sasagawa, S. Makinoda, Hiroshi Ichimura, Mosfequr Rahman, Alan Kingoro |
| المصدر: | Journal of Medical Virology. 83:1988-1996 |
| بيانات النشر: | Wiley, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Genotype, Cross-sectional study, Population, HIV Infections, Cervix Uteri, Comorbidity, Immunity, Virology, Cytology, Prevalence, medicine, Humans, education, Papillomaviridae, Vaginal Smears, Cervical cancer, education.field_of_study, business.industry, Papillomavirus Infections, HPV infection, HIV, virus diseases, Cancer, Middle Aged, medicine.disease, Kenya, female genital diseases and pregnancy complications, Cross-Sectional Studies, Infectious Diseases, Female, business |
| الوصف: | The aim of this study was to investigate an association between certain human papillomavirus (HPV) types and human immunodeficiency virus (HIV) infections. Sexually active females (n = 487; 19-61 years old) were enrolled in the study. Subjects underwent Pap testing and evaluations of HIV and HPV infection status on uterine cervical cell samples. HPV genotyping was performed using a Kurabo GeneSQUARE DNA microarray test. Overall, 23 HPV genotypes were detected, and the most prevalent HPV genotype was HPV-52, followed by HPV-39, -54, -45, -56, -53, -31, -42, -16, -68, and -51. HPV-30, -53, -54, -61, and -66, which are associated with abnormal cytology, are categorized as intermediate-risk in this study. Detection of both high- and intermediate-risk HPV types was significantly associated with cervical abnormality and HIV infection. Multivariate analysis revealed that some high-risk HPV types (HPV-31, -45, -51, -56, and -59) and most intermediate-risk HPV types were associated with HIV infection, while the high-risk types (HPV-16, -18, -33, -35, -39, -52, -58, and -68) were not. The oncogenic effect of the most malignant HPV types (e.g., HPV-16 and -18) appear to be lower, while that of intermediate-risk types are greater, in areas with a high prevalence of HIV infection. |
| تدمد: | 0146-6615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfa74ed3f04f98179ed357c1877dd80 https://doi.org/10.1002/jmv.22203 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4bfa74ed3f04f98179ed357c1877dd80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01466615 |
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