Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin
| العنوان: | Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin |
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| المؤلفون: | Hsin-Yi Tiffany Chen, Yoke Mooi Ng, Yves Ira A. Reyes, Carmine Coluccini, Yit Lung Khung |
| المصدر: | Molecules Volume 25 Issue 22 Molecules, Vol 25, Iss 5455, p 5455 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Magnetic Resonance Spectroscopy, Macromolecular Substances, Polymers, Supramolecular chemistry, Molecular Conformation, Doxorubicin loading, Pharmaceutical Science, Cyclotriveratrylene, macromolecular substances, Article, Analytical Chemistry, Supramolecular assembly, Hydrophobic effect, lcsh:QD241-441, chemistry.chemical_compound, symbols.namesake, Drug Delivery Systems, lcsh:Organic chemistry, Drug Discovery, Spectroscopy, Fourier Transform Infrared, Polyethyleneimine, Polycyclic Compounds, Physical and Theoretical Chemistry, supramolecular interaction, Polyethylenimine, Drug Carriers, Molecular Structure, Hydrogen bond, armed Cyclotriveratrylene, Organic Chemistry, technology, industry, and agriculture, Aromaticity, Models, Theoretical, Combinatorial chemistry, Cross-Linking Reagents, chemistry, Chemistry (miscellaneous), Doxorubicin, symbols, Molecular Medicine, van der Waals force |
| الوصف: | In this paper, a modified Cyclotriveratrylene was synthesized and linked to a branched Polyethylenimine, and this unique polymeric material was subsequently examined as a potential supramolecular carrier for Doxorubicin. Spectroscopic analysis in different solvents had shown that Doxorubicin was coordinated within the hollow-shaped unit of the armed Cyclotriveratrylene, and the nature of the host&ndash guest complex revealed intrinsic Van der Waals interactions and hydrogen bonding between the host and guest. The strongest interaction was detected in water because of the hydrophobic effect shared between the aromatic groups of the Doxorubicin and Cyclotriveratrylene unit. Density functional theory calculations had also confirmed that in the most stable coordination of Doxorubicin with the cross-linked polymer, the aromatic rings of the Doxorubicin were localized toward the Cyclotriveratrylene core, while its aliphatic chains aligned closer with amino groups, thus forming a compact supramolecular assembly that may confer a shielding effect on Doxorubicin. These observations had emphasized the importance of supramolecular considerations when designing a novel drug delivery platform. |
| وصف الملف: | application/pdf |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c09425a577dfa71cd06c22d23baf595 https://pubmed.ncbi.nlm.nih.gov/33233774 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4c09425a577dfa71cd06c22d23baf595 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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