Pharmacodynamics of temazepam in primary insomnia: Assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep
| العنوان: | Pharmacodynamics of temazepam in primary insomnia: Assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep |
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| المؤلفون: | Douwe D. Breimer, Rik C. Schoemaker, B. Kemp, Joop M. A. van Gerven, Meindert Danhof, Bert Tuk, Adam F. Cohen, H. A. C. Kamphuisen, Carl C. Peck, M. S. M. Pieters, Janine J. L. Oberyé |
| المصدر: | Clinical Pharmacology & Therapeutics. 62:444-452 |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.drug_class, Polysomnography, Primary Insomnia, Hypnotic, Temazepam, Physical medicine and rehabilitation, Predictive Value of Tests, Sleep Initiation and Maintenance Disorders, Surveys and Questionnaires, Saccades, medicine, Insomnia, Humans, Pharmacology (medical), Aged, Pharmacology, Sleep disorder, medicine.diagnostic_test, business.industry, Electroencephalography, Middle Aged, medicine.disease, Quantitative electroencephalography, Treatment Outcome, Anti-Anxiety Agents, Anesthesia, Female, Sleep onset, medicine.symptom, Sleep, business, medicine.drug |
| الوصف: | Background and objective quantitative electroencephalographic parameters and saccadic eye movements are frequently used as pharmacodynamic measures of benzodiazepine effect. We investigated the relationship between these measures and the hypnotic effect. Methods The correlation between the pharmacodynamic measures and sleep quality was determined in 21 patients with primary insomnia. The pharmacokinetic-pharmacodynamic relationships were characterized after administration of 20 mg oral temazepam. The hypnotic effect was determined on the basis of polysomnographic sleep recordings and a subjective sleep evaluation questionnaire. Correlations between pharmacodynamic measures and the improvement of sleep were investigated. Results The pharmacokinetic-pharmacodynamic relationships for the parameters derived from electroencephalography and saccadic eye movements showed considerable interindividual variability. Administration of temazepam led to a significant improvement in the objective parameters sleep period efficiency, wake time after sleep onset, and sleep efficiency and in the subjective assessment of sleep quality. No significant correlations were observed between the pharmacokinetic-pharmacodynamic-derived parameters and the improvement in objective or subjective sleep parameters. Conclusion In subjects with primary insomnia the administration of 20 mg oral temazepam results in changes in both the pharmacodynamic measures and in quality of sleep. No individual correlations between the pharmacodynamic measures and quality of sleep were observed. We concluded that the investigated pharmacodynamic measures are of value in the first assessment of clinical efficacy and for the selection of the dose(s) to be investigated in subsequent trials that aim at showing clinical efficacy. However, the conclusive quantification of clinical efficacy should be performed only on the basis of the clinical end point itself. Clinical Pharmacology & Therapeutics (1997) 62, 444–452; doi |
| تدمد: | 1532-6535 0009-9236 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0c0fc88268d1be45255ebeb71ea371 https://doi.org/10.1016/s0009-9236(97)90123-5 |
| رقم الأكسشن: | edsair.doi.dedup.....4c0c0fc88268d1be45255ebeb71ea371 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15326535 00099236 |
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