IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A
| العنوان: | IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A |
|---|---|
| المؤلفون: | Roberta Palla, Syna Miri, Carla Valsecchi, Frits R. Rosendaal, Paolo Bucciarelli, Marco Boscarino, Lucia Schiavone, Pier Mannuccio Mannucci, Flora Peyvandi |
| المصدر: | British Journal of Haematology. WILEY British Journal of Haematology |
| بيانات النشر: | WILEY, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Haemophilia A, haemophilia A, Hemophilia A, Gastroenterology, Subclass, Persistence (computer science), predictive biomarkers, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, IgG subclasses, Predictive biomarker, Factor VIII, business.industry, Infant, Hematology, Igg subclasses, medicine.disease, inhibitor, Child, Preschool, Immunoglobulin G, 030220 oncology & carcinogenesis, Concomitant, Female, Severe haemophilia A, business, Biomarkers, 030215 immunology |
| الوصف: | We investigated longitudinally the behaviour of anti-factor VIII (anti-FVIII) IgG subclasses for 6 months from inhibitor development in 43 patients from the Survey of Inhibitors in Plasma-Products Exposed Toddlers (SIPPET) trial who developed persistent or transient inhibitors. We first analysed 43 patients within 60 days post inhibitor detection. Then, 14 of these 43 patients were studied at five time points over 6 months. Our study showed that during the first 60 days, the risk of inhibitor persistence increased with the concomitant presence of an increasing number of IgG subclasses. Over the 6-month period post inhibitor detection, only the IgG2 subclass could be considered a hallmark of inhibitor persistence. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c21e193dfa40f2917eaa570a5761389 https://hdl.handle.net/1887/3277322 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4c21e193dfa40f2917eaa570a5761389 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |