Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root
| العنوان: | Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root |
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| المؤلفون: | M K Jayanthi, R N Suresha, Jyoti M Benni |
| المصدر: | Indian Journal of Pharmacology |
| بيانات النشر: | Medknow Publications, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Aegle marmelos, medicine.drug_class, Pharmacology, Percent Inhibition, Anti-inflammatory, chemistry.chemical_compound, In vivo, Edema, Medicine, Pharmacology (medical), granuloma, anti-inflammatory, business.industry, medicine.disease, Carrageenan, chemistry, visual_art, Granuloma, Immunology, visual_art.visual_art_medium, carrageenan, Bark, Analysis of variance, medicine.symptom, business, edema, Research Article |
| الوصف: | Aims and objectives: The purpose of this study was to evaluate and compare the anti-inflammatory activity of the aqueous root bark extract of Aegle marmelos (Bilwa) in experimental acute and chronic inflammatory animal models. Materials and Methods: Aqueous extract of root bark of Bilwa was prepared and tested for anti-inflammatory activity in albino rats weighing 150-280 grams. The animals were randomly divided into 3 groups of 6 each; one group served as control and other two groups received indomethacin and Bilwa orally 1 hour prior to experimentation. The in vivo anti-inflammatory activity was studied using the acute (Carrageenan induced paw edema) and chronic (Cotton pellet induced granuloma) animal models. Anti-inflammatory activity was expressed as Percent inhibition (PI). Statistical analysis was performed using One-way analysis of variance (ANOVA) followed by Scheffe's post hoc test. P < 0.05 was considered statistically significant. Results: The PI with indomethacin and Bilwa in carrageenan induced paw edema were 52.7% and 46% and in cotton pellet induced granuloma were 24.7% and 9.2% respectively. Indomethacin showed highly significant anti-inflammatory activity in both the models. However, Bilwa showed highly significant activity in acute model and but a trend of anti-inflammatory activity in chronic model studied. Conclusions: As Bilwa showed significant anti-inflammatory activity in the models studied, it can be a promising anti-inflammatory agent. |
| اللغة: | English |
| تدمد: | 1998-3751 0253-7613 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5952597a1e9c989f024af186543c5a http://europepmc.org/articles/PMC3153700 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4c5952597a1e9c989f024af186543c5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983751 02537613 |
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