Blood thicker than water: kinship, disease prevalence and group size drive divergent patterns of infection risk in a social mammal
| العنوان: | Blood thicker than water: kinship, disease prevalence and group size drive divergent patterns of infection risk in a social mammal |
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| المؤلفون: | Alastair J. Wilson, Andrew Robertson, Clare H. Benton, Robbie A. McDonald, Terry Burke, Richard J. Delahay, Dave J. Hodgson |
| المصدر: | Proceedings of the Royal Society B: Biological Sciences |
| بيانات النشر: | The Royal Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, relatedness, 0106 biological sciences, 0301 basic medicine, Infection risk, European badger, Prevalence, Mustelidae, Wildlife disease, 010603 evolutionary biology, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, law.invention, social structure, 03 medical and health sciences, law, kin structure, Bovine tuberculosis, Kinship, Animals, Tuberculosis, infection risk, bovine tuberculosis, Social Behavior, Research Articles, General Environmental Science, Population Density, Behavior, Animal, General Immunology and Microbiology, biology, Ecology, General Medicine, biology.organism_classification, Mycobacterium bovis, 030104 developmental biology, Transmission (mechanics), Female, Mammal, General Agricultural and Biological Sciences, Demography |
| الوصف: | The importance of social- and kin-structuring of populations for the transmission of wildlife disease is widely assumed but poorly described. Social structure can help dilute risks of transmission for group members, and is relatively easy to measure, but kin-association represents a further level of population sub-structure that is harder to measure, particularly when association behaviours happen underground. Here, using epidemiological and molecular genetic data from a wild, high-density population of the European badger (Meles meles), we quantify the risks of infection withMycobacterium bovis(the causative agent of tuberculosis) in cubs. The risk declines with increasing size of its social group, but this net dilution effect conceals divergent patterns of infection risk. Cubs only enjoy reduced risk when social groups have a higher proportion of test-negative individuals. Cubs suffer higher infection risk in social groups containing resident infectious adults, and these risks are exaggerated when cubs and infectious adults are closely related. We further identify key differences in infection risk associated with resident infectious males and females. We link our results to parent–offspring interactions and other kin-biased association, but also consider the possibility that susceptibility to infection is heritable. These patterns of infection risk help to explain the observation of a herd immunity effect in badgers following low-intensity vaccination campaigns. They also reveal kinship and kin-association to be important, and often hidden, drivers of disease transmission in social mammals. |
| تدمد: | 1471-2954 0962-8452 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd380e573556329b73f8c1c3874087b https://doi.org/10.1098/rspb.2016.0798 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4cd380e573556329b73f8c1c3874087b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712954 09628452 |
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