Prognostic significance of the tumour-adjacent tissue in head and neck cancers
| العنوان: | Prognostic significance of the tumour-adjacent tissue in head and neck cancers |
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| المؤلفون: | Jan Balvan, Hana Polanska, Rom Kostrica, Zuzana Horáková, Hana Binková, Marek Feith, Martina Raudenská, René Kizek, Jaromír Gumulec, Michal Masarik, Michaela Fojtu, Markéta Sztalmachová |
| المصدر: | Tumor Biology. 36:9929-9939 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, MMP2, medicine.medical_treatment, Biology, MMP9, Gene expression, Biomarkers, Tumor, Tumor Microenvironment, medicine, Humans, Metallothionein, Gene, Aged, Neoplasm Staging, Aged, 80 and over, Gene Expression Profiling, RNA, General Medicine, Middle Aged, Prognosis, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Biomarker (medicine), Female, Adjuvant |
| الوصف: | Even with significant advances in operative skills and adjuvant therapies, the overall survival of patients suffering with head and neck squamous cancers (HNSCC) is unsatisfactory. Accordingly, no clinically useful prognostic biomarkers have been found yet for HNSCC. Many studies analysed the expression of potential markers in tumour tissues compared to adjacent tissues. Nevertheless, due to the sharing of the same microenvironment, adjacent tissues show molecular similarity to tumour tissues. Thus, gene expression patterns of 94 HNSCC tumorous tissues were compared with 31 adjacent tissues and with 10 tonsillectomy specimens of non-cancer individuals. The genes analysed at RNA level using quantitative RT-PCR and correlated with clinico-pathological conditions were as follows: EGF, EGFR, MKI67, BCL2, BAX, FOS, JUN, TP53, VEGF, FLT1, MMP2, MMP9, MT1A and MT2A. The elevated MT2A, BAX, EGF and JUN expression was associated with the influence of tumour cells on the rearrangement of healthy tissues, as well as a significant shift in the BAX/BCL2 ratio. Our investigation also indicated that adjacent tissues play an important role in cancerogenesis by releasing several tumour-supporting factors such as EGF. A gradual increase in the metallothionein expression, from the lowest one in tonsillectomy samples to the highest ones in tumour samples, suggests that MT expression might be tissue reaction to the presence of tumour cells. The results of this study confirmed the significance of metallothionein in tumori-genesis and gave evidences for its use as a potential HNSCC biomarker. Furthermore, this study highlighted the importance of histologically normal tumour-adjacent tissue in prediction of HNSCC progress. |
| تدمد: | 1423-0380 1010-4283 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce2fa4d555e2334ae2eff09e003de04 https://doi.org/10.1007/s13277-015-3755-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4ce2fa4d555e2334ae2eff09e003de04 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14230380 10104283 |
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