أعرض في EDS

TIFA protein expression is associated with pulmonary arterial hypertension

التفاصيل البيبلوغرافية
العنوان: TIFA protein expression is associated with pulmonary arterial hypertension
المؤلفون: Wen Chung Yu, Hao Chih Chang, Ming-Daw Tsai, Shih Hsien Sung, Tong You Wade Wei, Pei Yu Wu, Chen Huan Chen
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Science, Interleukin-1beta, Cardiology, Diseases, Inflammation, 030204 cardiovascular system & hematology, Peripheral blood mononuclear cell, Article, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Humans, Adaptor Proteins, Signal Transducing, Pulmonary Arterial Hypertension, Multidisciplinary, Tumor Necrosis Factor-alpha, business.industry, NF-kappa B, Interleukin, Middle Aged, Endocrinology, medicine.anatomical_structure, Gene Expression Regulation, 030228 respiratory system, Pulmonary artery, Leukocytes, Mononuclear, Vascular resistance, Medicine, Female, Tumor necrosis factor alpha, medicine.symptom, business, Biomarkers, Ex vivo, Signal Transduction
الوصف: Tumor necrosis factor receptor-associated factor-interacting protein with a forkhead-associated domain (TIFA), a key regulator of inflammation, may be involved in the pathogenesis of pulmonary arterial hypertension (PAH). A total of 48 PAH patients (age 50.1±13.1 years, 22.9% men), 25 hypertensive subjects, and 26 healthy controls were enrolled. TIFA protein expression in peripheral blood mononuclear cells (PBMCs) and plasma interleukin (IL)-1β and tumor necrosis factor (TNF)-α were measured. Pulmonary arterial hemodynamics were derived from right heart catheterization. PAH patients had the highest expression of TIFA, TNF-α, and IL-1β. TIFA protein expression was significantly associated with IL-1β (r=0.94; PPP=0.006), and pulmonary vascular resistance (r=0.41; P=0.007). TIFA protein expression could independently predict the presence of PAH (odds ratio [95% confidence interval per-0.1 standard deviation]: 1.72 [1.37-2.16]; PEx vivo silencing of TIFA protein expression in PBMCs led to the suppression of the cellular expression of IL-1β and TNF-α. IL-1β and TNF-α mediated 80.4% and 56.6% of the causal relationship between TIFA and PAH, respectively, supporting the idea that TIFA protein is involved in the pathogenesis of PAH.
اللغة: English
تدمد: 2045-2322
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce6c2092ff7f67a3c94c410d16a9dee
https://doaj.org/article/f8f9a9e7f08c4807a4c315981a7a80ff
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....4ce6c2092ff7f67a3c94c410d16a9dee
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20452322