TIFA protein expression is associated with pulmonary arterial hypertension
العنوان: | TIFA protein expression is associated with pulmonary arterial hypertension |
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المؤلفون: | Wen Chung Yu, Hao Chih Chang, Ming-Daw Tsai, Shih Hsien Sung, Tong You Wade Wei, Pei Yu Wu, Chen Huan Chen |
المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports |
بيانات النشر: | Nature Portfolio, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Science, Interleukin-1beta, Cardiology, Diseases, Inflammation, 030204 cardiovascular system & hematology, Peripheral blood mononuclear cell, Article, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Humans, Adaptor Proteins, Signal Transducing, Pulmonary Arterial Hypertension, Multidisciplinary, Tumor Necrosis Factor-alpha, business.industry, NF-kappa B, Interleukin, Middle Aged, Endocrinology, medicine.anatomical_structure, Gene Expression Regulation, 030228 respiratory system, Pulmonary artery, Leukocytes, Mononuclear, Vascular resistance, Medicine, Female, Tumor necrosis factor alpha, medicine.symptom, business, Biomarkers, Ex vivo, Signal Transduction |
الوصف: | Tumor necrosis factor receptor-associated factor-interacting protein with a forkhead-associated domain (TIFA), a key regulator of inflammation, may be involved in the pathogenesis of pulmonary arterial hypertension (PAH). A total of 48 PAH patients (age 50.1±13.1 years, 22.9% men), 25 hypertensive subjects, and 26 healthy controls were enrolled. TIFA protein expression in peripheral blood mononuclear cells (PBMCs) and plasma interleukin (IL)-1β and tumor necrosis factor (TNF)-α were measured. Pulmonary arterial hemodynamics were derived from right heart catheterization. PAH patients had the highest expression of TIFA, TNF-α, and IL-1β. TIFA protein expression was significantly associated with IL-1β (r=0.94; PPP=0.006), and pulmonary vascular resistance (r=0.41; P=0.007). TIFA protein expression could independently predict the presence of PAH (odds ratio [95% confidence interval per-0.1 standard deviation]: 1.72 [1.37-2.16]; PEx vivo silencing of TIFA protein expression in PBMCs led to the suppression of the cellular expression of IL-1β and TNF-α. IL-1β and TNF-α mediated 80.4% and 56.6% of the causal relationship between TIFA and PAH, respectively, supporting the idea that TIFA protein is involved in the pathogenesis of PAH. |
اللغة: | English |
تدمد: | 2045-2322 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce6c2092ff7f67a3c94c410d16a9dee https://doaj.org/article/f8f9a9e7f08c4807a4c315981a7a80ff |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....4ce6c2092ff7f67a3c94c410d16a9dee |
قاعدة البيانات: | OpenAIRE |
تدمد: | 20452322 |
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