Intracranial hemorrhage in primary immune thrombocytopenia (ITP): 20 years’ experience in pediatrics
| العنوان: | Intracranial hemorrhage in primary immune thrombocytopenia (ITP): 20 years’ experience in pediatrics |
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| المؤلفون: | Mahmoud A El-Hawy, Omar Elalfy, Ilham Youssry, Hoda Hassab, Tamer Hassan, Mohsen Saleh Elalfy, Mohamed El-Shanshory, Khadiga Yehia Eltonbary, Ahmed M. Mansour, Islam Reda El Ghamry, Mohamed M. Badr, Marwa Abd El-hady, Khalid I Elsayh, Marwa Wahid, Mohamed H. Meabed |
| المصدر: | European Journal of Pediatrics. 180:1545-1552 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Purpura, Thrombocytopenic, Idiopathic, Pediatrics, medicine.medical_specialty, Platelet Count, business.industry, Incidence (epidemiology), Platelet Transfusion, Immune thrombocytopenia, nervous system diseases, Head trauma, hemic and lymphatic diseases, Pediatrics, Perinatology and Child Health, medicine, Humans, cardiovascular diseases, Significant risk, Neurologic sequelae, Good outcome, Child, business, Intracranial Hemorrhages |
| الوصف: | Incidence of intracranial hemorrhage (ICH) among children with primary immune thrombocytopenia (ITP) varies among different studies. We published data during the period of 1997-2007 of ICH in children with primary ITP, addressing risk factors and outcome. The aim of this study is to assess changes in incidence, risk factors, and outcome of ICH in children with ITP from last decade and to report the overall 20 years' experience. We compared 2008-2018 with the decade before it. Data of children with ITP and ICH during study period and ITP control cases were analyzed. Neurosurgical intervention and outcome were also reported. A total of 4340 children with primary ITP were evaluated. Twenty-five (0.63%) ICH events were reported over 2 decades. Head trauma, hematuria, and platelet counts 10 × 109/L were the risk factors mostly associated with ICH. Overall mortality was 24%, and a further 28% had neurologic sequelae. Neurosurgical intervention was done in 12% of cases with good outcome.Conclusion: Persistent platelet counts 10 × 109/L were a significant risk factor for ICH in both time periods, while head trauma and hematuria were more reported in the period of 2008-2018 as significant risk factors for ICH. Outcome was comparable in both periods. What is Known: • ICH is a rare complication of ITP; however, early recognition of risk factors and aggressive treatment might lead to complete recovery without sequalae. Platelet counts less than 10 × 109/L are the main risk factor for ICH. Few studies reported other significant risk factors. What is New: • Hematuria and head trauma are significant risk factors for ICH in ITP, in addition to having a persistently low platelet count 10 × 109/L. (more than 90 days in chronic ITP, 45 days in persistent and 21 days in acute ITP) • Combined treatment with IVIG and HDMP followed by platelet transfusion was associated with complete recovery without sequelae in almost 50% of patients. |
| تدمد: | 1432-1076 0340-6199 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfc9df21823ed30f2ddcefe86fb745c https://doi.org/10.1007/s00431-020-03923-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4cfc9df21823ed30f2ddcefe86fb745c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321076 03406199 |
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