Endothelial transcytosis in health and disease
| العنوان: | Endothelial transcytosis in health and disease |
|---|---|
| المؤلفون: | Maya Simionescu, Doina Popov, Anca Sima |
| المصدر: | Cell and Tissue Research. 335:27-40 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Inflammation, Histology, Endothelium, Vesicle, Cell, Endothelial Cells, Biological Transport, Epithelial Cells, Hyperlipidemias, Cell Biology, Biology, Proteomics, Pathology and Forensic Medicine, Cell biology, medicine.anatomical_structure, Transcytosis, Caveolae, Diabetes Mellitus, medicine, Animals, Humans, medicine.symptom, Transport Vesicles |
| الوصف: | The visionaries predicted the existence of transcytosis in endothelial cells; the cell biologists deciphered its mechanisms and (in part) the molecules involved in the process; the cell pathologists unravelled the presence of defective transcytosis in some diseases. The optimistic perspective is that transcytosis, in general, and receptor-mediated transcytosis, in particular, will be greatly exploited in order to target drugs and genes to exclusive sites in and on endothelial cells (EC) or underlying cells. The current recognition that plasmalemmal vesicles (caveolae) are the vehicles involved in EC transcytosis has moved through various phases from initial considerations of caveolae as unmovable sessile non-functional plasmalemma invaginations to the present identification of a multitude of molecules and a crowd of functions associated with these ubiquitous structures of endothelial and epithelial cells. Further understanding of the molecular machinery that precisely guides caveolae through the cells so as to reach the target membrane (fission, docking, and fusion), to avoid lysosomes, or on the contrary, to reach the lysosomes, and discharge the cargo molecules will assist in the design of pathways that, by manipulating the physiological route of caveolae, will carry molecules of choice (drugs, genes) at controlled concentrations to precise destinations. |
| تدمد: | 1432-0878 0302-766X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0adb7dfb93b5ce2561f00e74ad0cf2 https://doi.org/10.1007/s00441-008-0688-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4d0adb7dfb93b5ce2561f00e74ad0cf2 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320878 0302766X |
|---|