Resveratrol enhanced mitochondrial recovery from cryopreservation‐induced damages in oocytes and embryos
العنوان: | Resveratrol enhanced mitochondrial recovery from cryopreservation‐induced damages in oocytes and embryos |
---|---|
المؤلفون: | Hisataka Iwata |
المصدر: | Reproductive Medicine and Biology Reproductive Medicine and Biology, Vol 20, Iss 4, Pp 419-426 (2021) |
بيانات النشر: | Wiley, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | QH471-489, Mini Review, Mini Reviews, resveratrol, Biology, Mitochondrion, Resveratrol, cryopreservation, Diseases of the endocrine glands. Clinical endocrinology, Cryopreservation, chemistry.chemical_compound, SIRT1, Human fertilization, medicine, Reproduction, Embryogenesis, Embryo, Cell Biology, RC648-665, Oocyte, Cell biology, mitochondria, medicine.anatomical_structure, Reproductive Medicine, Mitochondrial biogenesis, chemistry |
الوصف: | Background Mitochondria play a crucial role in nuclear maturation, fertilization, and subsequent embryo development. Cryopreservation is an important assisted reproductive technology that is used worldwide for humans and domestic animals. Although mitochondrial quantity and quality are decisive factors for successful development of oocytes and embryos, cryopreservation induces mitochondrial dysfunction. Upon thawing, the damaged mitochondria are removed, and de novo synthesis occurs to restore the function of mitochondria. Resveratrol, 3,5,4′‐trihydroxystilbene, is a polyphenolic antioxidant that has versatile target proteins, among which sirtuin‐1 (SIRT1) is a key regulator of in mitochondrial biogenesis and degradation. Methods The present study is a literature review focusing on experiments involving the hypothesis that the activation of mitochondrial biogenesis and degradation following cryopreservation and warming by resveratrol may help mitochondrial recovery and improve oocyte and embryo development. Main findings and conclusion Resveratrol improves oocyte maturation and development and upregulates mitochondrial biogenesis and degradation. When vitrified‐warmed embryos are treated with resveratrol, it helps in mitochondrial regulation and recovery of embryos from cryopreservation‐induced damage. Conclusion Resveratrol treatment is a possible countermeasure against cryopreservation‐induced mitochondrial damage. Cryopreservation‐induced damage in embryos may be ameliorated by an activation of mitochondrial synthesis and degeneration. |
تدمد: | 1447-0578 1445-5781 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1b2b51680b3ead623a68b4755b8452 https://doi.org/10.1002/rmb2.12401 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....4d1b2b51680b3ead623a68b4755b8452 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14470578 14455781 |
---|