A Novel Netrin-1-Derived Peptide Enhances Protection against Neuronal Death and Mitigates of Intracerebral Hemorrhage in Mice
| العنوان: | A Novel Netrin-1-Derived Peptide Enhances Protection against Neuronal Death and Mitigates of Intracerebral Hemorrhage in Mice |
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| المؤلفون: | Lin Liu, Jian-Bo Cao, Jing Yang, Xiaojuan Zhu, Xiao-Xiao He, Hua-Li Yu, Kai-jie Liu, Zi-Xuan He |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 4829, p 4829 (2021) International Journal of Molecular Sciences Volume 22 Issue 9 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Peptide, Apoptosis, Mice, Netrin, Medicine, Biology (General), Spectroscopy, chemistry.chemical_classification, Behavior, Animal, Cell Death, General Medicine, Netrin-1, DCC Receptor, peptide, Computer Science Applications, Chemistry, medicine.anatomical_structure, Neuroprotective Agents, embryonic structures, Phosphorylation, neuroprotection, animal structures, Cell Survival, QH301-705.5, Central nervous system, Neuroprotection, Catalysis, Article, Inorganic Chemistry, Focal adhesion, Animals, Humans, Physical and Theoretical Chemistry, hemin, Molecular Biology, QD1-999, Cerebral Hemorrhage, Intracerebral hemorrhage, business.industry, Organic Chemistry, fungi, medicine.disease, intracerebral hemorrhage, Disease Models, Animal, HEK293 Cells, chemistry, Focal Adhesion Protein-Tyrosine Kinases, Cancer research, business |
| الوصف: | It has been reported that Netrin-1 is involved in neuroprotection following injury to the central nervous system. However, the minimal functional domain of Netrin-1 which can preserve the neuroprotection but avoid the major side effects of Netrin remains elusive. Here, we investigated the neuroprotective effect of a peptide E1 derived from Netrin-1′s EGF3 domain (residues 407–422). We found that it interacts with deleted colorectal carcinoma (DCC) to activate focal adhesion kinase phosphorylation exhibiting neuroprotection. The administration of the peptide E1 was able to improve functional recovery through reduced apoptosis in an experimental murine model of intracerebral hemorrhage (ICH). In summary, we reveal a functional sequence of Netrin-1 that is involved in the recovery process after ICH and identify a candidate peptide for the treatment of ICH. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d34dba2d6e592769ddc3714adce7b32 https://www.mdpi.com/1422-0067/22/9/4829 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4d34dba2d6e592769ddc3714adce7b32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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