Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat
| العنوان: | Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat |
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| المؤلفون: | Neil E. Grunberg, Bobbi K. Lewis, Eric M. Gold, L. Christine Turtzo, Dana D. Dean, Tiziana Coppola, Matthew D. Budde, Angela M. Yarnell, Lindsay Janes, Jacob Lescher, Joseph A. Frank |
| المصدر: | PLoS ONE, Vol 10, Iss 5, p e0126551 (2015) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pathology, Stromal cell, Traumatic brain injury, medicine.medical_treatment, Cell- and Tissue-Based Therapy, lcsh:Medicine, Brain damage, Mesenchymal Stem Cell Transplantation, Regenerative medicine, Intracardiac injection, Cardiac Catheters, medicine, Image Processing, Computer-Assisted, Animals, Humans, Treatment Failure, Rats, Wistar, lcsh:Science, Cells, Cultured, Multidisciplinary, business.industry, Mesenchymal stem cell, lcsh:R, Brain, Mesenchymal Stem Cells, Stem-cell therapy, medicine.disease, Magnetic Resonance Imaging, Rats, Disease Models, Animal, Brain Injuries, Histopathology, Administration, Intravenous, Female, lcsh:Q, medicine.symptom, business, Research Article |
| الوصف: | Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells ( |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d80fdfdcdcba5f71e9bf047f1fa6d6a http://europepmc.org/articles/PMC4422703?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4d80fdfdcdcba5f71e9bf047f1fa6d6a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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