The prognostic value of PET/CT evaluation with Deauville score on the recurrence and survival in diffuse large B-cell lymphoma: a multi-institutional study of KROG 17-02
| العنوان: | The prognostic value of PET/CT evaluation with Deauville score on the recurrence and survival in diffuse large B-cell lymphoma: a multi-institutional study of KROG 17-02 |
|---|---|
| المؤلفون: | Dongryul Oh, Keun Yong Eom, Mi Joo Chung, Jeong Won Lee, Jinhee Kim, Jong Hoon Lee, Woo Chul Kim |
| المصدر: | Clinical & Experimental Metastasis. 37:125-131 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_treatment, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, Antineoplastic Combined Chemotherapy Protocols, Stage (cooking), Aged, 80 and over, Hazard ratio, Chemoradiotherapy, General Medicine, Middle Aged, Prognosis, Survival Rate, Vincristine, 030220 oncology & carcinogenesis, Female, Lymphoma, Large B-Cell, Diffuse, Rituximab, medicine.drug, Adult, medicine.medical_specialty, Disease-Free Survival, 03 medical and health sciences, Fluorodeoxyglucose F18, Internal medicine, Republic of Korea, medicine, Humans, Propensity Score, Cyclophosphamide, Survival rate, Aged, Retrospective Studies, PET-CT, business.industry, medicine.disease, Confidence interval, Radiation therapy, 030104 developmental biology, Doxorubicin, Prednisone, Neoplasm Recurrence, Local, business, Diffuse large B-cell lymphoma, Follow-Up Studies |
| الوصف: | The Korean Radiation Oncology Group (KROG) assessed the value of Deauville score (DS) on 18F-fluorodeoxyglucose Positron emission tomography-computed tomography (FDG PET/CT) as a predictor of recurrence and survival after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy in diffuse large B-cell lymphoma (DLBCL). A total of 512 patients with stage I–III DLBCL who received six cycles of R-CHOP with or without radiation therapy (RT) and obtained treatment responses according to PET-CT imagings after R-CHOP ± RT were included. Patients were sorted into two arms; DS 4–5 arm (n = 24) was matched at a 1:2 ratio with DS 1–3 arm (n = 48) using propensity score matching method. After a median follow-up time of 37.2 months, the recurrence-free survival rate (86.6% vs. 66.8%, P = 0.041) and overall survival rate (86.9% vs. 62.2%, P = 0.009) at 5 years were significantly different between the DS 1–3 and DS 4–5 arms. DS 4–5 arm showed higher 5-years locoregional recurrence-free survival (88.8% vs. 74.3%, P = 0.155) and distant failure-free survival (91.1% vs. 84.3%, P = 0.333) than DS 1–3 arm. In the multivariate analysis, DS was still a significant factor for recurrence-free survival [hazard ratio (HR), 3.840 and confidence interval (CI), 1.068–13.806; P = 0.039] and overall survival rates (HR 4.453 and CI 1.274–15.562; P = 0.019). This study showed and validated that Deauville score of 4–5 of PET-CT imaging taken after full-course of R-CHOP chemotherapy with or without RT could predict recurrence-free survival and overall survival in DLBCL patients. |
| تدمد: | 1573-7276 0262-0898 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daf2515b8d0f8cbf088441dc3d1fa33 https://doi.org/10.1007/s10585-019-09992-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4daf2515b8d0f8cbf088441dc3d1fa33 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737276 02620898 |
|---|