Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior
| العنوان: | Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior |
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| المؤلفون: | M L Nelson, Sue Z. Sabol, Dean H. Hamer, Leo A. Sirota, S E Marcus, Gunzerath L, Craig Fisher, Dennis L. Murphy, Benjamin D. Greenberg, Cindy L. Brody, Hu S |
| المصدر: | Molecular Psychiatry. 5:181-188 |
| بيانات النشر: | Springer Science and Business Media LLC, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Genotype, Neurotic Disorders, medicine.medical_treatment, media_common.quotation_subject, Population, Nerve Tissue Proteins, Personality Assessment, Cellular and Molecular Neuroscience, mental disorders, medicine, Humans, Personality, Big Five personality traits, education, Molecular Biology, Serotonin transporter, Aged, media_common, Serotonin Plasma Membrane Transport Proteins, education.field_of_study, Membrane Glycoproteins, biology, Smoking, Membrane Transport Proteins, Middle Aged, Former Smoker, Neuroticism, Psychiatry and Mental health, behavior and behavior mechanisms, biology.protein, Smoking cessation, Anxiety, Female, medicine.symptom, Carrier Proteins, Psychology, psychological phenomena and processes, Clinical psychology |
| الوصف: | Cigarette smoking behavior is influenced by both personality traits and inherited factors. Previous research showed that neuroticism-a broad personality domain that includes anxiety, depression, impulsiveness and vulnerability-increases the risk of being a smoker, primarily because of difficulty in quitting. Neuroticism has also been associated with the 5-HTTLPR, a functional polymorphism in the promoter for the serotonin transporter gene. We used population and family-based methods to analyze the joint effects of the 5-HTTLPR and neuroticism on smoking behavior in a population of 759 never, current, and former smokers, all members of sib-pairs. Our main finding is that smoking behavior is influenced by an interaction between neuroticism and 5-HTTLPR genotype. Specifically, neuroticism was positively correlated with current smoking and negatively associated with smoking cessation in individuals and siblings with poorly transcribed 5-HTTLPR-S genotypes, but not in those with the more highly expressed 5-HTTLPR-L genotype. Individuals with both a 5-HTTLPR-S genotype and a high level of neuroticism had the greatest difficulty in quitting smoking. These data, if replicated, suggest that smoking behavior is more strongly influenced by the combination of the serotonin transporter gene and neuroticism than by either factor alone, and that personality scores and 5-HTTLPR genotype may predict the clinical efficacy of certain smoking cessation drugs. |
| تدمد: | 1476-5578 1359-4184 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db999f48531ff4ceda7860dff97ca5d https://doi.org/10.1038/sj.mp.4000690 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4db999f48531ff4ceda7860dff97ca5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765578 13594184 |
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