A randomized, open-label, comparative study of oral tranexamic acid and tranexamic acid microinjections in patients with melasma
| العنوان: | A randomized, open-label, comparative study of oral tranexamic acid and tranexamic acid microinjections in patients with melasma |
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| المؤلفون: | Swati Agarwal, Vinod K Khurana, Akhilesh V Thole, Tanu Anand, Rachita Misri, Sachin Kumar |
| المصدر: | Indian Journal of Dermatology, Venereology and Leprology, Vol 85, Iss 1, Pp 39-43 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Microinjections, Melasma, Administration, Oral, Dermatology, Melanosis, tranexamic acid, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, therapeutic studies, lcsh:Dermatology, Humans, Medicine, In patient, Prospective Studies, melasma, business.industry, Small sample, Middle Aged, lcsh:RL1-803, medicine.disease, Antifibrinolytic Agents, Clinical trials preparation, Index score, Treatment Outcome, Infectious Diseases, 030220 oncology & carcinogenesis, Anesthesia, Female, Open label, business, Tranexamic acid, Treatment Arm, medicine.drug |
| الوصف: | Background: Melasma poses a great challenge as its treatment modalities are unsatisfactory. Treatment using tranexamic acid is a novel concept. Aim: This study aimed to compare the therapeutic efficacy and safety of oral tranexamic acid and tranexamic acid microinjections in patients with melasma. Methods: This is a prospective, randomized, open-label study with a sample size of 64, 32 in each treatment arm. Thirty-two patients were administered localized microinjections (4 mg/ml) of tranexamic acid monthly in 1 arm, while in the other arm, 32 were given oral tranexamic acid 250 mg twice a day. Patients were followed up for 3 consecutive months. Clinical photographs were taken at each visit, and a modified melasma area and severity index scoring was performed at the beginning and end of treatment. Results: Improvement in melasma area and severity index score in the oral group was 57.5% as compared to 43.5% in the intralesional group. All 32 patients in the oral group (100%) showed >50% improvement, out of which 8 showed >75% improvement. In the intralesional group, 17 (53%) patients had >50% improvement, of which 3 had >75% improvement. The remaining 15 patients in this group had |
| اللغة: | English |
| تدمد: | 0973-3922 0378-6323 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd02479eb9c4be7fe90609a47d1561d http://www.ijdvl.com/article.asp?issn=0378-6323;year=2019;volume=85;issue=1;spage=39;epage=43;aulast=Khurana |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4dd02479eb9c4be7fe90609a47d1561d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09733922 03786323 |
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