A Retrospective Cohort Study of Sublingual Immunotherapy with Standardized Dermatophagoides farinae Drops for Allergic Rhinitis
| العنوان: | A Retrospective Cohort Study of Sublingual Immunotherapy with Standardized Dermatophagoides farinae Drops for Allergic Rhinitis |
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| المؤلفون: | Xingkai Ma, Huijun Yang, Jianbin Lu, Jianyong Liu, Xiaodan Gu, Yu Zhang, Geping Wu |
| المصدر: | Advances in Therapy. 38:2315-2322 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Sublingual Immunotherapy, medicine.medical_specialty, Dermatophagoides farinae, Visual analogue scale, business.industry, Incidence (epidemiology), Retrospective cohort study, General Medicine, Rhinitis, Allergic, Slit, Dermatology, Treatment Outcome, medicine, Animals, Humans, Pharmacology (medical), Sublingual immunotherapy, Antigens, Dermatophagoides, business, Adverse effect, Retrospective Studies, Nasal symptoms, Vas score |
| الوصف: | To evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with standardized Dermatophagoides farinae (Df) drops in monosensitized and polysensitized patients with allergic rhinitis (AR) and to analyze the adverse events (AEs).A retrospective analysis was performed using data for 68 patients with AR who received SLIT. The patients were divided into a monosensitized group (36 cases) and a polysensitized group (32 cases) based on serum-specific IgE test results. In the two groups of patients, total nasal symptoms score (TNSS), total medication score (TMS), visual analog scale (VAS) score, and AEs before treatment and at 1, 3, 6, and 12 months of treatment were evaluated.Compared with that before treatment, the TNSS, TMS, and VAS score in the monosensitized and polysensitized groups all decreased significantly at 3, 6, and 12 months of SLIT (all P 0.05). There were no significant differences in treatment efficacy indicators between the two groups at all treatment time points (all P 0.05). In terms of safety, compared with 1 month after initiating SLIT, the incidence of AEs in the monosensitized and polysensitized groups at 6 and 12 months of treatment significantly decreased (all P 0.05). There was a statistically significant decrease in the incidence of AEs in both groups at 6 months compared with 3 months of treatment (χSLIT with standardized Df drops has similar efficacy and safety for monosensitized and polysensitized patients with AR. AEs mostly occurred during the first 3 months of SLIT in both the monosensitized and polysensitized groups, and the incidence of AEs gradually decreased as the course of treatment extended. |
| تدمد: | 1865-8652 0741-238X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dec48e0bbb9189b8a66c40d4de54345 https://doi.org/10.1007/s12325-021-01686-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4dec48e0bbb9189b8a66c40d4de54345 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18658652 0741238X |
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