Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications
| العنوان: | Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications |
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| المؤلفون: | Lin Wu, James R Sowers, Yingmei Zhang, Jun Ren |
| المصدر: | Cardiovascular Research. 119:691-709 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine |
| الوصف: | Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic, and metabolomic abnormalities. Emerging evidence has recently consolidated the presence of robust DNA damage in a variety of cardiovascular disorders. DNA damage triggers a series of cellular responses termed DNA damage response (DDR) including detection of DNA lesions, cell cycle arrest, DNA repair, cellular senescence, and apoptosis, in all organ systems including hearts and vasculature. Although transient DDR in response to temporary DNA damage can be beneficial for cardiovascular function, persistent activation of DDR promotes the onset and development of CVDs. Moreover, therapeutic interventions that target DNA damage and DDR have the potential to attenuate cardiovascular dysfunction and improve disease outcome. In this review, we will discuss molecular mechanisms of DNA damage and repair in the onset and development of CVDs, and explore how DDR in specific cardiac cell types contributes to CVDs. Moreover, we will highlight the latest advances regarding the potential therapeutic strategies targeting DNA damage signalling in CVDs. |
| تدمد: | 1755-3245 0008-6363 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df49b3de7353c43dad64550c018bf07 https://doi.org/10.1093/cvr/cvac080 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4df49b3de7353c43dad64550c018bf07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17553245 00086363 |
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