A new method to model change in cutaneous blood flow due to mechanical skin irritation

التفاصيل البيبلوغرافية
العنوان: A new method to model change in cutaneous blood flow due to mechanical skin irritation
المؤلفون: D. Bauer, R. Grebe, Alain Ehrlacher
المصدر: Journal of Theoretical Biology. 238:588-596
بيانات النشر: Elsevier BV, 2006.
سنة النشر: 2006
مصطلحات موضوعية: Statistics and Probability, medicine.medical_specialty, Materials science, Contraction (grammar), Vasodilation, Blood volume, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Internal medicine, medicine, Anisotropy, General Immunology and Microbiology, Continuous modelling, business.industry, Applied Mathematics, Function (mathematics), Mechanics, General Medicine, Blood flow, Smooth muscle contraction, Laser Doppler velocimetry, Optical phenomena, Skin irritation, Modeling and Simulation, Cardiology, Irritation, Porous medium, General Agricultural and Biological Sciences, business
الوصف: Mechanical skin irritation creates vasodilation. Vasodilation of vascular networks induces increase in blood volume and blood velocity. Both can be measured by Laser Doppler Velocimetry. We propose in this article a method permitting comparison between experimental and numerical results. Experimental data was obtained by Laser Doppler Velocimetry. Numerical results were obtained by a continuous model of the vascular network. The model consists of three layers. First and last layer are described by anisotropic and heterogeneous porous media. They represent the irrigation and the drainage of the vascular system. The intermediate layer is described by a lumped parameter model that does not permit horizontal fluxes. All vessels are compliant. The permeabilities depend on the volumes of the specific layer. Skin irritation is modeled by a change in compliance of small arterial blood vessels. The comparison between experimental and numerical data is based on the model proposed by Bonner and Nossal [1981. Model for laser Doppler measurements of blood flow. Appl. Opt. 20, 2097–2107]. The model describes the Doppler frequency spectrum S ( ω ) as a function of the optical phenomena creating the frequency shift. The comparison is based on the model of the first moment M 1 ∼ ∫ ω S ( ω ) d ω . The variables of the first moment can be determined by results of the numerical model. We have shown, that it exists a linear relation between the change in compliance and the following increase in first moment. Using this linear relation experimental and numerical data can be compared.
تدمد: 0022-5193
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e11729068492e05c75eb46e154f3396
https://doi.org/10.1016/j.jtbi.2005.06.024
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....4e11729068492e05c75eb46e154f3396
قاعدة البيانات: OpenAIRE