Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies
| العنوان: | Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies |
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| المؤلفون: | Atsuko Tsutsumi, Tomomi Shimizu, Koji Matsuno, Yasushi Takamori, Hisahiro Kai, Rie Sawamura, Hiroki Yoshida, Masahiko Kurokawa, Yong Kun Park, Youhei Takeshita, Ken Yasukawa, Kimiyasu Shiraki, Wataru Watanabe |
| المصدر: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2011 (2011) |
| بيانات النشر: | Hindawi Publishing Corporation, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Article Subject, business.industry, lcsh:Other systems of medicine, Propolis, medicine.disease_cause, lcsh:RZ201-999, Virus, Herpes simplex virus, Complementary and alternative medicine, Antigen, Oral administration, In vivo, Interferon, Toxicity, Immunology, medicine, business, medicine.drug, Research Article |
| الوصف: | Ethanol extracts (AF-06, 07, and 08, 10 mg/kg) of Brazilian propolis were administered orally to cutaneously herpes simplex virus type 1 (HSV-1)-infected mice three times daily on days 0 to 6 after infection to evaluate their efficacies against HSV-1 infection and significantly limited development of herpetic skin lesions. AF-07 and 08 significantly reduced virus titers in brain and/or skin on day 4 without toxicity, but AF-08 had no anti-HSV-1 activityin vitro. AF-06 and 08 significantly enhanced delayed-type hypersensitivity (DTH) to inactivated HSV-1 antigen in infected mice. Oral AF-08-administration significantly augmented interferon (IFN)-γproduction by HSV-1 antigen from splenocytes of HSV-1-infected mice, while direct exposure of splenocytes of infected mice to AF-06 significantly elevated IFN-γproductionin vitro. Thus, AF-08 might have components that are activein vivoeven after oral administration and those of AF-06 might be active onlyin vitro. Because DTH is a major host defense for intradermal HSV-1 infection, augmentation of DTH response by AF-06 or 08, directly or indirectly, respectively, may contribute to their efficacies against HSV-1 infection. In addition, AF-06 and 07 possibly contain anti-HSV-1 components contributing to their efficacies. Such biological activities of Brazilian propolis may be useful to analyze its pharmacological actions. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1741-4288 1741-427X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4fd5321bd1fd336d52aa4a8537798d http://europepmc.org/articles/PMC3118910 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4e4fd5321bd1fd336d52aa4a8537798d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
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