Oligonucleotide aptamers: potential novel molecules against viral hepatitis
| العنوان: | Oligonucleotide aptamers: potential novel molecules against viral hepatitis |
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| المؤلفون: | Mansour Salehi, Hojjat Sadeghi-Aliabadi, Mina Mirian, Hossein Khanahmad, Leila Darzi |
| المصدر: | Research in Pharmaceutical Sciences, Vol 12, Iss 2, Pp 88-98 (2017) Research in Pharmaceutical Sciences |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Dissolution rate, medicine.drug_class, Aptamer, Nanosizing, Review Article, Nanocrystal, Biology, Monoclonal antibody, 03 medical and health sciences, Nanoparticle, Pharmacy and materia medica, medicine, General Pharmacology, Toxicology and Pharmaceutics, Aptamer Technology, Hepatitis, Oligonucleotide, medicine.disease, Virology, RS1-441, 030104 developmental biology, Nanosuspension, biology.protein, Antibody, Viral hepatitis, dissolution rate, nanocrystal, nanoparticle, nanosuspension, nanosizing |
| الوصف: | Viral hepatitis, as an international public health concern, seriously affects communities and health system. In recent years, great strides have been taken for development of new potential tools against viral hepatitis. Among these efforts, a valuable strategy introduced new molecules called "aptamers". Aptamers as potential alternatives for antibodies could be directed against any protein in infected cells and any components of viral particles. In this review, we will focus on recent advances in the diagnosis and treatment of viral hepatitis based on aptamer technology. In recent years, various types of aptamers including RNA and DNA were introduced against viral hepatitis. Some of these aptamers can be utilized for early and precise diagnosis of hepatitis infections and other group selected as therapeutic tools against viral targets. Designing diagnostic and therapeutic platforms based on aptamer technology is a promising approach in viral infections. The obtained aptamers in the recent years showed obvious potential for use as diagnostic and therapeutic tools against viral hepatitis. Although some modifications to increase the biostability and half-life of aptamers are underway, it seems these molecules will be a favorable substitute for monoclonal antibody in near future. |
| اللغة: | English |
| تدمد: | 1735-9414 1735-5362 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e52eb37bf189403e93c162a5f942cf8 http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=2;spage=88;epage=98;aulast= |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4e52eb37bf189403e93c162a5f942cf8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17359414 17355362 |
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