Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
| العنوان: | Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 |
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| المؤلفون: | Anne M. Romanic, Douglas W. P. Hay, Shelagh Wilson, Eliot H. Ohlstein, Nambi Aiyar, Calvert Louden, Wu-Schyong Liu, Henry M. Sarau, George I. Glover, Stephen A. Douglas, Stephen Dudley Holmes, Charles F. Sauermelch, Nabil Elshourbagy, Usman Shabon, John D. Martin, Robert W. Coatney, James J. Foley, Johathan K. Chambers, Derk J. Bergsma, Catherine E. Ellis, Dean E. McNulty, Robert S. Ames, John J. Trill, Zhaohui Ao, Robert N. Willette, Jeffrey M. Stadel, Jyoti Disa |
| المصدر: | Nature. 401:282-286 |
| بيانات النشر: | Springer Science and Business Media LLC, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, Agonist, medicine.medical_specialty, DNA, Complementary, medicine.drug_class, Urotensins, Molecular Sequence Data, Central nervous system, Receptors, Cell Surface, Biology, Urotensin-II receptor, Cell Line, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, chemistry.chemical_compound, GTP-Binding Proteins, Internal medicine, medicine, Animals, Humans, Vasoconstrictor Agents, Tissue Distribution, Amino Acid Sequence, Cloning, Molecular, Receptor, Orphan receptor, Multidisciplinary, Base Sequence, Sequence Homology, Amino Acid, Rats, Macaca fascicularis, medicine.anatomical_structure, Endocrinology, chemistry, Calcium, medicine.symptom, Urotensin-II, Vasoconstriction |
| الوصف: | Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally isolated from fish spinal cords1,2, and which has recently been cloned from man3. Here we describe the identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 (refs 4, 5) and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor. Goby and human U-II bind to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human U-II is found within both vascular and cardiac tissue (including coronary atheroma) and effectively constricts isolated arteries from non-human primates. The potency of vasoconstriction of U-II is an order of magnitude greater than that of endothelin-1, making human U-II the most potent mammalian vasoconstrictor identified so far. In vivo, human U-II markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction. Furthermore, as U-II immunoreactivity is also found within central nervous system and endocrine tissues, it may have additional activities. |
| تدمد: | 1476-4687 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6f6a769e8aa255ebc1716ff22de776 https://doi.org/10.1038/45809 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4e6f6a769e8aa255ebc1716ff22de776 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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