Asteltoxins from the Entomopathogenic Fungus Pochonia bulbillosa 8-H-28
| العنوان: | Asteltoxins from the Entomopathogenic Fungus Pochonia bulbillosa 8-H-28 |
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| المؤلفون: | Kaori Nakajima, Hiroyasu Doi, Yuichi Kasahara, Ryuichi Sawa, Hayamitsu Adachi, Ken Tateishi, Nobuo Hosokawa, Akio Nomoto, Yumiko Kubota |
| المصدر: | Journal of Natural Products. 78:1730-1734 |
| بيانات النشر: | American Chemical Society (ACS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Fat body, Cell Survival, Stereochemistry, Pharmaceutical Science, Spodoptera litura, Spodoptera, Biology, Ring (chemistry), Analytical Chemistry, chemistry.chemical_compound, Japan, Depsipeptides, Drug Discovery, Animals, Asteltoxin, Nuclear Magnetic Resonance, Biomolecular, Octane, Pharmacology, Pochonia bulbillosa, Molecular Structure, Organic Chemistry, biology.organism_classification, Complementary and alternative medicine, chemistry, Pyrones, Larva, Hypocreales, Entomopathogenic fungus, Molecular Medicine |
| الوصف: | New asteltoxins C (3) and D (4) were found in the extract of the entomopathogenic fungus Pochonia bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was isolated, and structural analysis led to a revision of the structure of asteltoxin B. Compounds 2 and 4 have a novel tricyclic ring system connected to a dienyl α-pyrone structure. Compound 3 has a 2,8-dioxabicyclo[3.3.0]octane ring similar to that of asteltoxin (1). Compound 3 showed potent antiproliferative activity against NIAS-SL64 cells derived from the fat body of Spodoptera litura larvae, while 2 and 4 were inactive. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e944db6f45f907a741899126efda3a9 https://doi.org/10.1021/np500676j |
| رقم الأكسشن: | edsair.doi.dedup.....4e944db6f45f907a741899126efda3a9 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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