Modeling Superparamagnetic Particles in Blood Flow for Applications in Magnetic Drug Targeting
| العنوان: | Modeling Superparamagnetic Particles in Blood Flow for Applications in Magnetic Drug Targeting |
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| المؤلفون: | Shahriar Afkhami, Pengtao Yue, Iris Rukshin, Josef Mohrenweiser |
| المصدر: | Fluids, Vol 2, Iss 2, p 29 (2017) Fluids; Volume 2; Issue 2; Pages: 29 |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | magnetic drug targeting, superparamagnetic nanoparticles, blood flow, Materials science, Quantitative Biology::Tissues and Organs, Physics::Medical Physics, 02 engineering and technology, lcsh:Thermodynamics, Tracking (particle physics), 01 natural sciences, 010305 fluids & plasmas, Quantitative Biology::Cell Behavior, Nuclear magnetic resonance, lcsh:QC310.15-319, 0103 physical sciences, Diffusion (business), Brownian motion, lcsh:QC120-168.85, Fluid Flow and Transfer Processes, Mechanical Engineering, Mechanics, Blood flow, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Magnetic field, Flow (mathematics), Magnet, lcsh:Descriptive and experimental mechanics, 0210 nano-technology, Superparamagnetism |
| الوصف: | Magnetic drug targeting is a technique that involves the binding of medicine to magnetizable particles to allow for more specific transport to the target location. This has recently come to light as a method of drug delivery that reduces the disadvantages of conventional, systemic treatments. This study developed a mathematical model for tracking individual superparamagnetic nanoparticles in blood flow in the presence of an externally applied magnetic field. The model considers the magnetic attraction between the particles and the external magnet, influence of power law flow, diffusive interaction between the particles and blood, and random collisions with red blood cells. A stochastic system of differential equations is presented and solved numerically to simulate the paths taken by particles in a blood vessel. This study specifically focused on localized cancer treatment, in which a surface tumor is accessed through smaller blood vessels, which are more conducive to this delivery method due to slower flow velocities and smaller diameters. The probability of the particles reaching the tumor location is found to be directly dependent on ambient factors; thus, diffusion through Brownian motion and red blood cell collisions, different magnetic field and force models, blood viscosities, and release points are considered. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2311-5521 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee02f795da8dd52419db3232973b9ea http://www.mdpi.com/2311-5521/2/2/29 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4ee02f795da8dd52419db3232973b9ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23115521 |
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